Statins and angiogenesis: Is it about connections?

Autor:	Jawahar L. Mehta, Bum-Yong Kang, Junaid A. Khan, Paul L. Hermonat, Magomed Khaidakov, Wenze Wang
Rok vydání:	2009
Předmět:	Simvastatin Umbilical Veins Endothelium Angiogenesis Biophysics Neovascularization Physiologic Angiogenesis Inhibitors Pharmacology Biology Biochemistry Neovascularization Mice Antigens CD Cell Movement Cell Adhesion medicine Animals Humans Rosuvastatin cardiovascular diseases Rosuvastatin Calcium Molecular Biology Aorta Cells Cultured Cell Proliferation Tube formation Sulfonamides Matrigel Neovascularization Pathologic nutritional and metabolic diseases Cell Biology Cadherins Fluorobenzenes Mice Inbred C57BL Pyrimidines medicine.anatomical_structure Immunology Endothelium Vascular Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Ex vivo medicine.drug
Zdroj:	Biochemical and Biophysical Research Communications. 387:543-547
ISSN:	0006-291X
DOI:	10.1016/j.bbrc.2009.07.057
Popis:	Statins, inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, have been shown to induce both angiogenic and angiostatic responses. We attempted to resolve this controversy by studying the effects of two different statins, rosuvastatin and simvastatin, in two different assay systems. In the matrigel angiogenesis assay, both statins enhanced tube formation by human umbilical vein endothelial cells (HUVECs, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90399af082c4a98ed0b8ce1293067ac https://doi.org/10.1016/j.bbrc.2009.07.057 Zobrazit plný text záznamu Full Text from ScienceDirect