Tissue reactions induced by different embolising agents in cerebral arteriovenous malformations: a histopathological follow-up
| Autor: | Martin Stichenwirth, Irene Sulzbacher, Johannes A. Hainfellner, Andreas Gruber, Peter R. Mazal |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male Vasculitis Silicon medicine.medical_specialty Time Factors Adolescent Fibrin Catheterization Pathology and Forensic Medicine law.invention Central nervous system disease law medicine Humans Cyanoacrylates Child Aged Aged 80 and over biology Vascular disease business.industry Anatomical pathology Enbucrilate Middle Aged medicine.disease Embolization Therapeutic Capillaries Cerebral arteriovenous malformations Surgery Cyanoacrylate Polyvinyl Alcohol biology.protein Female Histopathology Bucrylate business Follow-Up Studies |
| Zdroj: | Pathology. 38:28-32 |
| ISSN: | 0031-3025 |
| DOI: | 10.1080/00313020500455795 |
| Popis: | Comparative histopathological analysis was performed in 47 incompletely embolised and resected cerebral arteriovenous malformations (AVMs).Thirty-three AVMs were embolised with n-butyl-cyanoacrylate (NBCA), four with iso-butyl-cyanoacrylate (IBCA), seven with polyvinyl alcohol particles (PVA), one with a fibrin mixture, one with silicon pellets, and one with microcatheter balloons. Maximum exposure time (MET) of the embolising agent (interval between embolisation and surgery) ranged from24 hours to 80 months. All AVMs were investigated regarding angionecrosis, angiofibrosis, acute inflammation, chronic inflammation, foreign-body reactions, vascular calcification, blood admixture to embolising cast, and capillary recanalisation within the AVMs. These parameters were correlated with MET, comparing different embolising agents, age, and sex.A typical sequence of events depending on MET is observed in all embolised AVMs: acute inflammation with mural angionecrosis is soon replaced by prominent chronic granulomatous vasculitis, which remains stable and is detectable for a very long time, even in AVMs with a MET of more than 6 years.Capillary recanalisation is always present in incompletely embolised AVMs, detectable after 3 months of MET, irrespective of the embolising agent used. Age and sex does not influence pattern and time course of tissue lesions and recanalisation in incompletely embolised AVMs. |
| Databáze: | OpenAIRE |
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