Sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery: A randomized clinical trial
| Autor: | Margaret Fathy Fayez, Hazem Saad El-Dine Mohamed, Essam R. Othman, Diaa Eldeen M. Abd El Aal, Mohammed K. Ali, Ahmed M. Abbas |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Hematocrit lcsh:Gynecology and obstetrics law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Obstetrics and Gynaecology oxytocin medicine Elective Cesarean Delivery 030212 general & internal medicine Sublingual misoprostol Misoprostol lcsh:RG1-991 misoprostol 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry Obstetrics and Gynecology postpartum hemorrhage Oxytocin Anesthesia Shivering Gestation medicine.symptom business medicine.drug |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 55, Iss 6, Pp 791-795 (2016) |
| ISSN: | 1028-4559 |
| DOI: | 10.1016/j.tjog.2016.02.019 |
| Popis: | Objective This study compares the efficacy of sublingual misoprostol versus intravenous oxytocin in reducing bleeding during and after cesarean delivery. Materials and methods A randomized clinical trial conducted on 120 pregnant women at term (37–40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either sublingual misoprostol 400 μg or intravenous infusion of 20 units of oxytocin after delivery of the neonate. The main outcome measures were blood loss at and 2 hours after cesarean delivery, change in hematocrit value, need for any additional oxytocic drugs, and drug-related side effects. Results The overall mean blood loss was significantly lower in the misoprostol group compared to the oxytocin group (490.75 ± 159.90 mL vs. 601.08 ± 299.49 mL; p = 0.025). However, changes in hematocrit level (pre- and postpartum) was comparable between both groups. There was a need for additional oxytocic therapy in 16.7% and 23.3% after use of misoprostol and oxytocin, respectively ( p = 0.361). Incidence of side effects such as shivering and metallic taste were significantly higher in the misoprostol group compared to the oxytocin group ( p Conclusions Sublingual misoprostol is more effective than intravenous infusion of oxytocin in reducing blood loss during and after cesarean delivery. However, occurrence of temporary side effects such as shivering and metallic taste was more frequent with the use of misoprostol. |
| Databáze: | OpenAIRE |
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