Recurrent Atypical Hemolytic Uremic Syndrome in Children With Acute Lymphoblastic Leukemia Undergoing Maintenance Chemotherapy

Autor:	Bülent Özgönenel, Kanta Bhambhani, Gaurav Kapur, Süreyya Savaşan, Richard J.H. Smith, Geoffrey Cheng
Rok vydání:	2018
Předmět:	0301 basic medicine medicine.medical_specialty Pancytopenia Lymphoblastic Leukemia medicine.medical_treatment Antineoplastic Agents Disease pathogenesis urologic and male genital diseases Gastroenterology Maintenance Chemotherapy 03 medical and health sciences 0302 clinical medicine Recurrence hemic and lymphatic diseases Internal medicine Atypical hemolytic uremic syndrome medicine Humans Child Childhood Acute Lymphoblastic Leukemia Atypical Hemolytic Uremic Syndrome Maintenance chemotherapy Chemotherapy business.industry Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Kidney Diseases business
Zdroj:	Journal of Pediatric Hematology/Oncology. 40:560-562
ISSN:	1077-4114
DOI:	10.1097/mph.0000000000000987
Popis:	Chemotherapy-associated myelosuppression and renal dysfunction is not uncommon during childhood acute lymphoblastic leukemia (ALL) therapy. Here we report 2 cases of atypical hemolytic uremic syndrome (aHUS) presenting with pancytopenia and renal dysfunction that developed during maintenance chemotherapy characterized by hypocomplementemia. Both cases experienced recurrence after resolution of the initial aHUS episode upon resumption of chemotherapy, raising a possible contributory role for chemotherapy in the disease pathogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ffac9b358635167aa90f1d1613561e https://doi.org/10.1097/mph.0000000000000987 Zobrazit plný text záznamu