Effectiveness and Duration of Intramuscular Antimotion Sickness Medications
| Autor: | Mary J. Wood, Malcolm E. Mims, Charles D. Wood, John J. Stewart |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Time Factors Motion Sickness medicine.medical_treatment Scopolamine Gastric motility Pharmacology Placebo Injections Intramuscular Promethazine Parasympatholytic Route of administration Caffeine Humans Medicine Pharmacology (medical) Ephedrine Saline business.industry medicine.disease Motion sickness Anesthesia Female business medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 32:1008-1012 |
| ISSN: | 0091-2700 |
| Popis: | Motion sickness inhibits gastric motility, making the oral route ineffective for medications. The intramuscular route is an effective alternative. The rotating chair was used to produce the M 111 level of motion sickness on the Graybiel Symptom Scale. The intramuscular medications given 30 minutes before rotation were compared with placebo (saline, 1 mL) for effectiveness and duration in increasing the number of tolerated head movements. Average placebo number of head movements was 294. Promethazine 25 mg increased head movements by 78% (P < .05), with a duration of 12 hours. Scopolamine 0.2 mg increased head movements by 91% (P < .05), with a duration of 4 hours. The effect of caffeine 250 mg and ephedrine 25 mg was not significant. When combined with scopolamine, ephedrine produced an 32% additive effect. Scopolamine 0.08 mg, 0.1 mg, and 0.2 mg and also promethazine 12.5 mg and 25 mg were significant (P < .05). Promethazine appears to be the drug of choice for intramuscular use because of a longer duration and a high level of effectiveness. Scopolamine was of high effectiveness, but had a duration of 4 hours. It was eight times as potent by the intramuscular as by the oral route. |
| Databáze: | OpenAIRE |
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