Comparison of various surrogate obesity indicators as predictors of cardiovascular mortality in four European populations
| Autor: | Tiina Laatikainen, Qing Qiao, Rachel Dankner, Richard W Morris, Coen D.A. Stehouwer, Pekka Jousilahti, J. Tuomilehto, X. Song, Stefan Söderberg, Altan Onat, John S Yudkin |
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| Přispěvatelé: | Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), RS: CARIM School for Cardiovascular Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Medicine (miscellaneous) body mass index Disease 030204 cardiovascular system & hematology abdominal obesity Cohort Studies 03 medical and health sciences 0302 clinical medicine Waist–hip ratio Internal medicine Environmental health stature medicine Humans Obesity Prospective Studies 030212 general & internal medicine Abdominal obesity Aged Proportional Hazards Models 2. Zero hunger Nutrition and Dietetics Somatotypes Waist-Hip Ratio Proportional hazards model business.industry Surrogate endpoint Middle Aged medicine.disease mortality Body Height 3. Good health Europe Endocrinology Cardiovascular Diseases Obesity Abdominal Body Composition Female Waist Circumference medicine.symptom business Body mass index Cohort study waist |
| Zdroj: | European Journal of Clinical Nutrition, 67(12), 1298-1302. Nature Publishing Group |
| ISSN: | 1476-5640 0954-3007 |
| Popis: | Body mass index (BMI) is the most commonly used surrogate marker for evaluating the risk of cardiovascular disease (CVD) mortality in relation to general obesity, while abdominal obesity indicators have been proposed to be more informative in risk prediction.A prospective cohort study consisting of 46 651 Europeans aged 24-99 years was conducted to investigate the relationship between CVD mortality and different obesity indicators including BMI, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), A Body Shape Index (ABSI) and waist-to-hip-to-height ratio (WHHR). Hazard ratio (HR) was estimated by the Cox proportional hazards model using age as timescale, and compared using paired homogeneity test.During a median follow-up of 7.9 years, 3435 participants died, 1409 from CVD. All obesity indicators were positively associated with increased risk of CVD mortality, with HRs (95% confidence intervals) per standard deviation increase of 1.19 (1.12-1.27) for BMI, 1.29 (1.21-1.37) for WC, 1.28 (1.20-1.36) for WHR, 1.35 (1.27-1.44) for WSR, 1.34 (1.26-1.44) for ABSI and 1.34 (1.25-1.42) for WHHR in men and 1.37 (1.24-1.51), 1.49 (1.34-1.65), 1.45 (1.31-1.60), 1.52 (1.37-1.69), 1.32 (1.18-1.48) and 1.45 (1.31-1.61) in women, respectively. The prediction was stronger with abdominal obesity indicators than with BMI or ABSI (P0.05 for all paired homogeneity tests). WSR appeared to be the strongest predictor among all the indicators, with a linear relationship with CVD mortality in both men and women.Abdominal obesity indicators such as WC, WHR, WSR and WHHR, are stronger predictors for CVD mortality than general obesity indicator of BMI. |
| Databáze: | OpenAIRE |
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