Pharmacokinetic properties of the synthetic cannabinoid JWH-018 and of its metabolites in serum after inhalation

Autor: Cora Wunder, Anna Geraths, Johannes G. Ramaekers, Werner Pogoda, Eef L. Theunissen, Stefan W. Toennes, Alexander Paulke
Přispěvatelé: RS: FPN NPPP II, Section Psychopharmacology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Indoles
Synthetic cannabinoids
medicine.medical_treatment
Metabolite
Clinical Biochemistry
Pharmaceutical Science
Pilot Projects
Pharmacology
01 natural sciences
Analytical Chemistry
chemistry.chemical_compound
0302 clinical medicine
Liquid chromatography–mass spectrometry
Tandem Mass Spectrometry
Drug Discovery
Metabolites
JWH-018
Spectroscopy
media_common
Inhalation
Chemistry
QUANTITATIVE MEASUREMENT
Substance Abuse Detection
OMEGA
medicine.drug
Drug
EXTRACTION
media_common.quotation_subject
HUMAN URINE
Naphthalenes
VALIDATION
03 medical and health sciences
Pharmacokinetics
medicine
WHOLE-BLOOD
MS/MS
Humans
TANDEM MASS-SPECTROMETRY
Liquid chromatography-mass spectrometry
IDENTIFICATION
Cannabinoids
Illicit Drugs
010401 analytical chemistry
QUANTIFICATION
0104 chemical sciences
Cannabinoid
030217 neurology & neurosurgery
Chromatography
Liquid
Zdroj: Journal of Pharmaceutical and Biomedical Analysis, 140, 215-222. Elsevier
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2017.03.043
Popis: Each year, synthetic cannabinoids are occurring in high numbers in the illicit drug market, but data on their pharmacology and toxicology are scarcely available. Therefore, a pilot study was performed to assess adverse effects of JWH-018, which is one of the oldest and best known synthetic cannabinoids. Six subjects inhaled smoke from 2 and 3mg JWH-018. The drug and nine of its metabolites were analyzed in their blood samples taken during the following 12h by liquid chromatography-mass spectrometry (LC-MSMS). The maximum concentration of JWH-018 reached 2.9-9.9ng/ml after inhalation and markedly decreased during the next 1.5h, followed by a multiexponential decline (t1/2 in median 1.3h and 5.7h). The concentration of the pentanoic acid metabolite was slightly higher than that of the 3-, 4- and 5-hydroxypentyl metabolites and of the 6-hydroxyindol metabolite. The data also suggest a multiexponential decline and slow terminal elimination of JWH-018 and all metabolites. The detection of JWH-018 and of its metabolites in serum requires high analytical sensitivity. The pharmacokinetic properties of inhaled JWH-018 are similar to that of THC. A slow terminal elimination of drug and metabolites may lead to accumulation in chronic users.
Databáze: OpenAIRE
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