Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability
| Autor: | Brigette Soltis-Vaughan, Ryan Edwards, Soonjo Hwang, Sahil Bajaj, William F. Garvey, James R. Blair, Arica Lerdahl, Ji Woo Seok, Alexandra Bohn, Christopher J. Kratochvil |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Adolescent superior frontal gyrus Prefrontal Cortex Audiology Irritability computer.software_genre insula Superior temporal gyrus Atrophy Voxel Humans Medicine Radiology Nuclear Medicine and imaging Affective Symptoms gray matter volume Child Left superior frontal gyrus Gyrification Research Articles Radiological and Ultrasound Technology business.industry Patient Acuity gyrification cortical thickness medicine.disease Magnetic Resonance Imaging Irritable Mood superior temporal gyrus Neurology Superior frontal gyrus Female Neurology (clinical) Anatomy medicine.symptom business computer Insula Research Article |
| Zdroj: | Human Brain Mapping |
| ISSN: | 1097-0193 1065-9471 |
| DOI: | 10.1002/hbm.25571 |
| Popis: | Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto‐striatal‐temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel‐based morphometry and surface‐based morphometry. One hundred and eight adolescents (46 youths with severe irritability and 62 healthy youths, average age = 14.08 years, standard deviation = 2.36) were scanned with a T1‐weighted MRI sequence. The severity of irritability was measured using the affective reactivity index. In youths with severe irritability, there was decreased CT, GMV, and LGI in the right superior frontal gyrus (SFG) compared to healthy youths, and negative correlations between these indices of the SFG and irritability. Our findings suggest that structural deficits in the SFG, potentially related to its role in inhibitory control, may be critical for the neurobiology of irritability. There was decreased CT, GMV, and LGI in the right superior frontal gyrus (SFG) compared to healthy youths, and negative correlations between these indices of the SFG and irritability. Our findings suggest that structural deficits in the SFG, potentially related to its role in inhibitory control, may be critical for the neurobiology of irritability. |
| Databáze: | OpenAIRE |
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