Optical coherence tomography angiography in multiple sclerosis: A cross-sectional study

Autor: Maurizio Fossarello, Roberta Farci, Eleonora Cocco, Jessica Frau, Giacom Diaz, Arturo Carta
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Fovea Centralis
genetic structures
Nerve fiber layer
Pathology and Laboratory Medicine
Diagnostic Radiology
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Tomography
Neurons
Multidisciplinary
Radiology and Imaging
Neurodegenerative Diseases
Ganglion
medicine.anatomical_structure
Neurology
Optic nerve
Medicine
Anatomy
Cellular Types
Tomography
Optical Coherence
Research Article
medicine.medical_specialty
Multiple Sclerosis
Ganglion Cells
Imaging Techniques
Ocular Anatomy
Science
Immunology
Research and Analysis Methods
Retina
Autoimmune Diseases
03 medical and health sciences
Signs and Symptoms
Ocular System
Diagnostic Medicine
Ophthalmology
medicine
Humans
False Positive Reactions
Optic neuritis
business.industry
Multiple sclerosis
Fovea centralis
Biology and Life Sciences
Optic Nerve
Retinal
Cell Biology
medicine.disease
Demyelinating Disorders
Axons
eye diseases
Capillaries
Cross-Sectional Studies
chemistry
Case-Control Studies
Cellular Neuroscience
030221 ophthalmology & optometry
Eyes
Clinical Immunology
sense organs
Clinical Medicine
Atrophy
business
Head
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 15, Iss 7, p e0236090 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: ObjectivesTo evaluate retinal axonal density and retinal capillary flow density (CFD) variations in patients affected by multiple sclerosis (MS) as documented by Optical Coherence Tomography Angiography (OCT-A).Material and methodsA cross-sectional study was performed in a tertiary university eye hospital on 94 eyes from 48 MS patients compared to 37 eyes from 23 matched controls. MS patients were divided in two groups: those with previous episodes of optic neuritis (MS ON+, 71.4%) and those without any previous visual complaint (no optic neuritis group, MS ON, 28.6%). Patients underwent macular and optic nerve head OCT-A with Optovue XR Avanti (Optovue, Freemont, California) after that preliminary evaluation of the ganglion cell complex (GCC) and of the retinal nerve fiber layer (RNFL) was achieved for each single eye by SD-OCT. CFD was evaluated in three different retinal layers of MS patients and controls: superficial capillary plexus (SCP), deep capillary plexus (DCP) and the choriocapillaris layer (CL). Each layer was analyzed in 18 preset subregions automatically detected by the system. CFD values were then correlated to the RNFL thickness and GCC thickness in the groups: p values were computed by t-tests between each group of MS patients and controls. A p-value of ResultsA significant difference in the overall CFD values was found between ON+ and ON- patients when compared to controls in 18 subregions of SCP. Furthermore, a significant difference was found between MS patients and controls in 16 subregions analyzed corresponding to the CL layer without difference between the two MS subgroups (ON+ and ON-).ConclusionsOCT-A when performed at the optic nerve head level and at the macular region is characterized by a reduction of retinal perfusion in a significant portion of MS patients independently if they had a previous history of optic nerve inflammation or not.
Databáze: OpenAIRE
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