Early and late onset pre-eclampsia and small for gestational age risk in subsequent pregnancies

Autor: Henk Groen, Paul P. van den Berg, Ben W.J. Mol, Anita C.J. Ravelli, H. Marike Boezen, Thomas Bernardes
Přispěvatelé: Reproductive Origins of Adult Health and Disease (ROAHD), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Life Course Epidemiology (LCE), Medical Informatics, APH - Aging & Later Life, APH - Methodology, APH - Quality of Care, ARD - Amsterdam Reproduction and Development, APH - Health Behaviors & Chronic Diseases
Rok vydání: 2020
Předmět:
Gestational hypertension
Maternal Health
Intrauterine growth restriction
Blood Pressure
Vascular Medicine
Pediatrics
Labor and Delivery
Families
Child Development
Endocrinology
0302 clinical medicine
Pre-Eclampsia
Pregnancy
Risk Factors
Medicine and Health Sciences
Medicine
Prospective Studies
Registries
030212 general & internal medicine
Children
reproductive and urinary physiology
Netherlands
030219 obstetrics & reproductive medicine
Multidisciplinary
Obstetrics
Age Factors
Obstetrics and Gynecology
female genital diseases and pregnancy complications
Hypertension
Infant
Small for Gestational Age
Gestation
Female
Infants
Research Article
Adult
medicine.medical_specialty
Child Growth
Endocrine Disorders
Science
Late onset
Preeclampsia
03 medical and health sciences
Hypertensive Disorders in Pregnancy
Diabetes Mellitus
Humans
Eclampsia
Growth Restriction
business.industry
medicine.disease
Pregnancy Complications
Age Groups
Metabolic Disorders
People and Places
Birth
Women's Health
Small for gestational age
Population Groupings
business
Zdroj: PLoS ONE, 15(3):0230483. PUBLIC LIBRARY SCIENCE
PLoS ONE, 15(3):e0230483. Public Library of Science
PLoS ONE, Vol 15, Iss 3, p e0230483 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Background Pre-eclampsia shares pathophysiology with intrauterine growth restriction. Objective To investigate whether delivery of a small for gestational age (SGA) infant in the 1st pregnancy increases the risk of early and late onset pre-eclampsia in the 2nd pregnancy. Conversely, we investigated whether pre-eclampsia in the 1st pregnancy impacts SGA risk in the 2nd pregnancy. Study design We studied a cohort from the Dutch Perinatal Registry of 265,031 women with 1st and 2nd singleton pregnancies who delivered between 2000 and 2007. We analyzed 2nd pregnancy risks of early and late onset pre-eclampsia—defined by delivery before or after 34 gestational weeks—as well as SGA below the 5th and between the 5th and 10th percentiles risks with multivariable logistic regressions. Interaction terms between 1st pregnancy hypertension, pre-eclampsia, SGA, and delivery before or after 34 gestational weeks were included in the regressions. Results First pregnancy early onset pre-eclampsia increased risk of SGA th percentile (OR 2.1, 95% CI 1.7–2.7) in the 2nd pregnancy. Late onset pre-eclampsia increased the SGA th percentile marginally (OR 1.1, 95% CI 1.0–1.3). In the absence of 1st pregnancy hypertensive disorder, women who delivered an SGA infant in their 1st pregnancy were at increased risk of 2nd pregnancy late onset pre-eclampsia (SGA th: OR 2.05, 95% CI 1.58–2.66; SGA 5–10th: OR 1.39, 95% CI 1.01–1.93). Early onset 2nd pregnancy pre-eclampsia risk was also increased, but this was only statistically significant for women who delivered an SGA infant below the 5th percentile in the 1st pregnancy (SGA th: OR 2.44, 95% CI 1.19–5.00; SGA 5–10th: OR 1.69, 95% CI 0.68–4.24;). Conclusion Women with 1st pregnancy early onset pre-eclampsia have increased risk of SGA th percentile in the 2nd pregnancy. SGA in the 1st pregnancy increases pre-eclampsia risk in the 2nd pregnancy even in the absence of hypertensive disorders in the 1st pregnancy, although absolute risks remain low. These findings strengthen the evidence base associating intrauterine growth restriction with early onset pre-eclampsia.
Databáze: OpenAIRE
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