Combined Analysis of AFP and HCCR-1 as an Useful Serological Marker for Small Hepatocellular Carcinoma: A Prospective Cohort Study
| Autor: | Zhang, Guoxin, Ha, Seon-Ah, Kim, Hyun K., Yoo, Jinah, Kim, Sanghee, Lee, Youn S., Hur, Soo Y., Kim, Yong W., Kim, Tae E., Park, Yong G., Wang, Jing, Yang, Yang, Xu, Zekuan, Song, Eun Y., Huang, Zuhu, Jirun, Peng, Zhongtian, Jin, Shishi, Qiao, Zhuqingqing, Cui, Lei, Gong, Kim, Jin W. |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Carcinoma Hepatocellular Hepatocellular carcinoma AFP Clinical Biochemistry Proto-Oncogene Mas HCCR-1 Proto-Oncogene Proteins Biomarkers Tumor Genetics Humans Prospective Studies Molecular Biology neoplasms Early Detection of Cancer Aged lcsh:R5-920 Liver Neoplasms Biochemistry (medical) General Medicine Middle Aged digestive system diseases Tumor Burden ROC Curve biomarker Female Other alpha-Fetoproteins lcsh:Medicine (General) |
| Zdroj: | Disease Markers, Vol 32, Iss 4, Pp 265-271 (2012) Disease markers |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world. The only serological marker widely used for the diagnosis of HCC is alpha-fetoprotein (AFP). Despite that AFP is widely used for the diagnosis of HCC, it has a limit as a serological marker due to its low sensitivity and specificity. The human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported as a new biomarker for HCC. To further evaluate the HCCR-1 as a biomarker for HCC, we conducted the prospective cohort study. We evaluated the significance of simultaneous measurement of 2 tumor markers in the diagnosis of HCC in China, Japan and Korea. Two markers for HCC, AFP and HCCR-1, were measured in the sera obtained from 1,338 patients at the time of initial diagnosis of HCC. Of the 1338 HCC patients, 616 (46%) and 686 (51.3%) were sero-positive for AFP and HCCR-1, respectively. The positive rate for HCC was increased up to 74.1% in combined use of AFP and HCCR-1. Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa. More importantly, the diagnostic rate for small HCC (< 2 cm) was significantly improved in the combined analysis of AFP and HCCR-1 to 56.9% although it was only 40.1% and 23.4% in the single analysis of HCCR-1 and AFP, respectively. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP. |
| Databáze: | OpenAIRE |
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