Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
| Autor: | Molly C. Kottemann, Agata Smogorzewska |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Genome instability
congenital hereditary and neonatal diseases and abnormalities DNA Repair DNA damage DNA repair Biology medicine.disease_cause Article chemistry.chemical_compound Fanconi anemia hemic and lymphatic diseases FANCD2 medicine Animals Humans FANCL Genetics Multidisciplinary Ethanol Stem Cells nutritional and metabolic diseases DNA medicine.disease Fanconi Anemia Complementation Group Proteins Cell Transformation Neoplastic Fanconi Anemia chemistry Cancer research Carcinogenesis |
| Zdroj: | Nature. 493(7432) |
| ISSN: | 1476-4687 |
| Popis: | The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the Crick strands of DNA, impede replication and transcription. Inappropriate repair of interstrand crosslinks causes genomic instability, leading to cancer; conversely, the toxicity of crosslinking agents makes them a powerful chemotherapeutic. Fanconi anaemia proteins can promote stem-cell function, prevent tumorigenesis, stabilize replication forks and inhibit inaccurate repair. Recent advances have identified endogenous aldehydes as possible culprits of DNA damage that may induce the phenotypes seen in patients with Fanconi anaemia. |
| Databáze: | OpenAIRE |
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