Interactions of opiates and prostaglandins E with regard to cyclic AMP in striatal tissue of rats in vitro
| Autor: | U. Havemann, Klaus Kuschinsky |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Narcotics Met-enkephalin medicine.medical_specialty medicine.medical_treatment Pharmacology toxicology In Vitro Techniques chemistry.chemical_compound Internal medicine Cyclic AMP biosynthesis Cyclic AMP medicine Animals Drug Interactions Pharmacology Chemistry Prostaglandins E General Medicine Corpus Striatum In vitro Rats Endocrinology Morphine lipids (amino acids peptides and proteins) Antagonism medicine.drug Prostaglandin E |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 302:103-106 |
| ISSN: | 1432-1912 0028-1298 |
| Popis: | The effects of prostaglandins E on the concentration of cyclic AMP (cAMP) and a possible antagonism of opiates vs. prostaglandins E were studied in homogenates and in slices of rat striata in vitro. In homogenates, PGE1 or PGE2 did not affect the synthesis of cAMP. Morphine slightly lowered the cAMP synthesis, in presence or absence of PGE1 or PGE2. In slices, PGE2 significantly elevated the cAMP concentrations, either in presence or in absence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine. Morphine, met-enkephalin and levorphanol, but not dextrorphan, antagonized this rise of cAMP. The effect of morphine was antagonized by naloxone. Adenosine or an elevation of K+-ions raised the cAMP concentrations, and PGE2 induced a further increase. In presence of elevated K+-ions or adenosine, however, morphine did not antagonize the PGE2-induced rise of cAMP concentration. It is suggested that under some experimental conditions described in the literature, endogenous activators of cAMP formation, e.g. adenosine, might mask the inhibitory effect of opiates on stimulation of opiates on stimulation of cAMP synthesis induced by prostaglandins E. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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