Meta‐analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin‐Exacerbated Respiratory Disease
| Autor: | Alex E Wright, En Shuo Hsu, James A Cowthran, David C Moffatt, Yong Fang Kuo, Mohamad R Chaaban |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Ovid medline medicine.medical_treatment Aspirin-induced asthma Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Aspirin tolerant asthma Humans 030223 otorhinolaryngology Desensitization (medicine) Aspirin business.industry Anti-Inflammatory Agents Non-Steroidal medicine.disease Respiratory Function Tests 030228 respiratory system Otorhinolaryngology Desensitization Immunologic Meta-analysis Quality of Life Respiration Disorders Asthma Aspirin-Induced Surgery Aspirin exacerbated respiratory disease business medicine.drug |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 164:11-18 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/0194599820932137 |
| Popis: | The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta-analysis.Embase and OVID Medline databases.A systematic review of published articles on outcomes following aspirin desensitization in any language for relevant articles was performed in February 2019. Outcomes included sinonasal quality-of-life assessment, sense-of-smell scores, FEV-1 (forced expiratory volume in 1 second), and medication/steroid use.Thirteen studies met the inclusion criteria out of 6055 articles screened. Aspirin desensitization resulted in significant improvement in FEV-1 and reduction in asthma medication/steroid use (Aspirin desensitization appears to be effective in improving pulmonary outcomes and should be considered in the treatment of patients with aspirin-exacerbated respiratory disease. However, good-quality studies are still needed to determine the ideal protocol tailored to individual patients. |
| Databáze: | OpenAIRE |
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