Studies on the genotoxicity of beryllium sulphate in vitro and in vivo
| Autor: | John Ashby, Flora Ratpan, Mary A. Morgan, R.D. Callander, Gary D. Stoner, M. Ishidate |
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| Rok vydání: | 1990 |
| Předmět: |
Adenoma
Male Salmonella typhimurium Lung Neoplasms Mice Inbred A Pharmacology Toxicology medicine.disease_cause Chinese hamster Lethal Dose 50 Mice Cricetulus In vivo Cricetinae Genetics medicine Animals Bioassay Cells Cultured Carcinogen Micronucleus Tests biology Chemistry Lethal dose biology.organism_classification respiratory tract diseases Liver Toxicity Immunology Carcinogens Mice Inbred CBA Erythropoiesis Beryllium Genotoxicity Mutagens |
| Zdroj: | Mutation Research/Genetic Toxicology. 240:217-225 |
| ISSN: | 0165-1218 |
| DOI: | 10.1016/0165-1218(90)90061-6 |
| Popis: | There is limited evidence that beryllium is a lung carcinogen to man, and several compounds of beryllium are carcinogenic to the lungs of the rat, rabbit and monkey. One such compound is beryllium sulphate (BeSO 4 · 4H 2 O). This soluble salt has been evaluated in a range of genotoxicity tests. It was non-mutagenic to Salmonella typhimurium (strains TA1535, 1537, 1538, 98 and 100) when evaluated in the plate-incorporation assay at dose levels up to 5 mg/plate (± induced rat-liver S9 mix). It was also non-clastogenic to Chinese hamster lung (CHL) cells cultured in vitro. When dosed to male CBA mice via oral gavage at dose levels of 80% and 50% of the medium lethal dose (2.3 and 1.4 g/kg, respectively) it failed to increase the incidence of micronucleated polychromatic erythrocytes in the bone marrow (sampled at 24, 48 and 72 h post-dosing). However, a marked depression of erythropoiesis was evident 24 h after dosing suggestive of beryllium-mediated bone-marrow toxicity. When tested in the strain A mouse lung tumour bioassay, BeSO 4 induced a significant increase in the number of tumour-bearing animals but not in the number of lung tumours per animal. These findings are discussed within the contexts of other genotoxicity data published for BeSO 4 , and of current strategies for the detection of possible human carcinogens. |
| Databáze: | OpenAIRE |
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