Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
| Autor: | Dominick G. A. Burton, Richard G. A. Faragher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence Aging Cell ox-LDL Disease Type 2 diabetes Review Article 03 medical and health sciences Mice 0302 clinical medicine Diabetes mellitus Insulin-Secreting Cells Neoplasms medicine Adipocytes Animals Humans Obesity Molecular Targeted Therapy Progenitor cell Cellular Senescence business.industry Diabetes medicine.disease Lipoproteins LDL Ageing Disease Models Animal 030104 developmental biology medicine.anatomical_structure Glucose Diabetes Mellitus Type 2 Cardiovascular Diseases Cancer research Kidney Diseases Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery Kidney disease |
| Zdroj: | Biogerontology |
| ISSN: | 1573-6768 1389-5729 |
| Popis: | Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes is a major risk factor in the development of additional health conditions, such as cardiovascular disease, kidney disease and cancer. Since senescent cells can drive disease development, obesity and diabetes can potentially create an environment that accelerates cell senescence within other tissues of the body. This can consequently manifest as age-related biological impairments and secondary diseases. Cell senescence in cell types linked with obesity and diabetes, namely adipocytes and pancreatic beta cells will be explored, followed by a discussion on the role of obesity and diabetes in accelerating ageing through induction of premature cell senescence mediated by high glucose levels and oxidised low-density lipoproteins. Particular emphasis will be placed on accelerated cell senescence in endothelial progenitor cells, endothelial cells and vascular smooth muscle cells with relation to cardiovascular disease and proximal tubular cells with relation to kidney disease. A summary of the potential strategies for therapeutically targeting senescent cells for improving health is also presented. |
| Databáze: | OpenAIRE |
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