Laser Doppler Flowmetry as a method of analysis for the evaluation of chemo - induced oral mucositis: A pilot study
| Autor: | Paulo Sérgio da Silva Santos, Marcelo Júnior Zanda, Raquel D’Aquino Garcia Caminha, Emanoele Paixão da Silva Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
business.industry
Cancer therapy Statistical difference neoplasms microcirculation Method of analysis Laser Doppler velocimetry medicine.disease chemotherapy World health lcsh:RK1-715 Chemotherapy cycle laser-doppler flowmetry lcsh:Dentistry Mucositis antineoplastic agents Medicine In patient Nuclear medicine business General Dentistry oral mucositis |
| Zdroj: | Journal of Oral Research, Vol 9, Iss 5, Pp 392-399 (2020) |
| ISSN: | 0719-2479 0719-2460 |
| Popis: | espanolAntecedentes: La mucositis oral (MO) es una inflamacion de la mucosa oral debido a la terapia del cancer, que compromete la calidad de vida del paciente. La flujometria laser Doppler (FLD) es un metodo no invasivo para monitorear el flujo sanguineo microvascular (FS) en tiempo real. Objetivo: Desarrollar un metodo para evaluar la FS en la mejilla de la region geniana en pacientes sometidos a quimioterapia por FLD y comparar los grados de MO y dolor con la evaluacion del FS. Material y Metodos: La evaluacion de la MO se realizo utilizando las escalas de la Organizacion Mundial de la Salud (OMS) y la Escala de Evaluacion de la Mucositis Oral (OMAS) y la escala analogica visual para la evaluacion del dolor. Para el analisis de flujometria se utilizo un flujometro laser Doppler (moorVMSTM™, longitud de onda de 780 nm y sonda VP3), fijado por un soporte de resina acrilica; La sonda VP3 se coloco en la region geniana y la cabeza del paciente se estabilizo con una almohada para el cuello para una medicion precisa. Se utilizo la prueba de Wilcoxon para comparar los resultados de la flujometria en los tiempos estudiados. Se utilizo el coeficiente de correlacion de Pearson para evaluar las relaciones entre FS y las escalas de la OMS, OMAS y analogicas visuales. Resultados: Se incluyeron 11 pacientes de ambos sexos, con edades comprendidas entre 30 y 78 anos, con MO. Se observo un aumento del FS cutaneo en los momentos iniciales de la MO, con reduccion progresiva durante el ciclo de quimioterapia. Hubo una diferencia estadistica (p EnglishBackground: Oral mucositis (OM) is an inflammation of the oral mucosa due to cancer therapy that compromises the patient’s quality of life. Laser Doppler flowmetry (LDF) is a non-invasive method to monitor microvascular blood flow (BF) in real-time. Purpose: Develop a method to evaluate BF in the genian region cheek in patients undergoing chemotherapy by LDF and compare the degrees of OM and pain with evaluation of BF. Material and methods: Evaluation of OM was performed using the World Health Organization (WHO) and Oral Mucositis Assessment Scale (OMAS) scales and the visual analog scale for pain evaluation. For flowmetry analysis, a laser Doppler flowmeter (moorVMSTM™, 780 nm wavelength and VP3 probe), fixed by an acrylic resin support was used; VP3 probe was positioned on the genian region and the patient’s head was stabilized with a neck pillow for an accurate measurement. The Wilcoxon test was used to compare the flowmetry results at the studied times. The Pearson correlation coefficient was used to evaluate relationships between BF and the WHO, OMAS and visual analog scales. Results: Eleven patients of both sexes, aged between 30 and 78 years, with OM were included. An increase in cutaneous BF was observed at the initial times of OM, with progressive reduction during the chemotherapy cycle. There was a statistical difference (p |
| Databáze: | OpenAIRE |
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