50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms
| Autor: | Robert G. Roeder |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Transcription Genetic Extramural Eukaryotic transcription Eukaryota RNA Historical Article Computational biology History 20th Century Biology Biochemistry History 21st Century Article Metric expansion of space 03 medical and health sciences 0302 clinical medicine Structural Biology Transcription (biology) Parallel complexity Turning point Molecular Biology 030217 neurology & neurosurgery Transcription Factors 030304 developmental biology |
| Zdroj: | Nat Struct Mol Biol |
| ISSN: | 1545-9985 1545-9993 |
| DOI: | 10.1038/s41594-019-0287-x |
| Popis: | The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes represented a major turning point in the field that, with subsequent elucidation of the distinct structures and functions of these enzymes, catalyzed an avalanche of further studies. In this Review, written from a personal and historical perspective, I highlight foundational biochemical studies that led to the discovery of an expanding universe of the components of the transcriptional and regulatory machineries, and a parallel complexity in gene-specific mechanisms that continue to be explored to the present day. |
| Databáze: | OpenAIRE |
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