| Autor: |
N. Valyraki, E. Maillart, V. Pourcher, N. Shor, S. Tran, M. Boudot de la Motte, C. Houillier, F. Domont, E. Morvan, M. Touat, M. Del Mar Amador, J. Aboab, B. Mathon, A. Hesters, C. Vignal-Clermont, C. Dehais, S. Bonnin, F. Lafitte, N. Villain, S. Varnous, O. Gout, M. Eloit, C. Rodriguez, R. Deschamps |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Revue Neurologique. 179:361-367 |
| ISSN: |
0035-3787 |
| Popis: |
The role of Human pegivirus (HPgV) in patients with encephalitis has been recently questioned. We present cases of 4 patients with similar clinical, biological, and radiological characteristics, including a past history of transplantation with long-term immunosuppression and a progressive course of severe and predominantly myelitis, associated in 3 cases with optic neuropathy causing blindness. Extensive workup was negative but analysis of the CSF by use of pan-microorganism DNA- and RNA-based shotgun metagenomics was positive for HPgV. This case series further supports the hypothesis of HPgV CNS infection and highlights the utility of metagenomic next-generation sequencing of CSF in immunocompromised patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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