Metaplastic lipid-rich carcinoma of the breast
| Autor: | Zsuzsanna Varga, Christiane Robl, Max A. Spycher, Rosmarie Caduff, Daniel Burger |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Vimentin Pathology and Forensic Medicine Cytokeratin Lipid droplet Metaplasia medicine Carcinoma Humans Lipid-Rich Carcinoma biology Biopsy Needle Carcinoma Ductal Breast Lumpectomy General Medicine Middle Aged medicine.disease Lipids Microscopy Electron biology.protein Female medicine.symptom Breast carcinoma |
| Zdroj: | Pathology International. 48:912-916 |
| ISSN: | 1440-1827 1320-5463 |
| Popis: | A case of lipid-rich mammary carcinoma identified in a lumpectomy specimen from a 56-year-old female is presented. The tumor showed features of poorly differentiated invasive ductal carcinoma of clear-cell phenotype. Cytoplasmic lucency was mainly accounted for by the accumulation of neutral fat and, to a lesser degree, glycogen. Tinctorial properties included positivity of tumor cells with Sudan III dye and diastase-sensitive periodic acid-Schiff staining. Ultrastructural examination confirmed the presence of abundant cytoplasmic lipid droplets and some glycogen rosettes. On immunohistochemistry, most tumor cells reacted for cytokeratin, vimentin and S-100 protein, and there was focal expression of carcinoembryogenic antigen. A minority of tumor cell nuclei expressed progesterone receptors. As an additional feature, part of the lesion exhibited chondroid metaplasia. Lipid-rich carcinoma of the breast is exceedingly rare and, to our knowledge, no such example harboring metaplastic elements has been described previously. |
| Databáze: | OpenAIRE |
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