Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders
| Autor: | Jason Lazar, Anna V. Rozenboym, Sasha L. Fulton, Lakshmi Thiramangalakdi, Haroon Kamran, Jean Tang, John G. Kral, Venkatesh Panthangi, Jeremy D. Coplan, Tarique D. Perera, Michael J. Owens, Yang Liu, Charles B. Nemeroff, Leonard A. Rosenblum, Louis Salciccioli |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Physiology Context (language use) 030204 cardiovascular system & hematology Biochemistry lcsh:RC346-429 lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Internal medicine Heart rate medicine Original Research Article Molecular Biology lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:Neurology. Diseases of the nervous system Thrifty phenotype Endocrine and Autonomic Systems lcsh:QP351-495 Stroke volume medicine.disease Mood lcsh:Neurophysiology and neuropsychology Mood disorders Anxiety medicine.symptom Psychology 030217 neurology & neurosurgery Anxiety disorder |
| Zdroj: | Neurobiology of Stress, Vol 8, Iss, Pp 202-210 (2018) Neurobiology of Stress |
| ISSN: | 2352-2895 |
| Popis: | Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a “thrifty phenotype” throughout the life cycle. For instance, ELS induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced “behavioral plasticity”, which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories. Herein, we test the hypothesis whether a thrifty phenotype induced by ELS is peripherally evident as hypotrophy of cardiac structure and function, raising the possibility that certain mood disorders may represent maladaptive physiological and central thrift adaptations. Methods: 14 adult bonnet macaques (6 males) exposed to the maternal variable foraging demand (VFD) model of ELS were compared to 20 non-VFD adult subjects (6 males). Left ventricle end-diastolic dimension (LVEDD), Left ventricle end-systolic dimension (LVESD) and stroke volume (SV) were calculated using echocardiography. Blood pressure and heart rate were measured only in females. Previously obtained neurobehavioral correlates available only in males were analyzed in the context of cardiac parameters. Results: Reduced LVESD (p |
| Databáze: | OpenAIRE |
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