tRNA as an active chemical scaffold for diverse chemical transformations
| Autor: | Anand Minajigi, Christopher S. Francklyn |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Peptidoglycan synthesis
Membrane lipids Biophysics Peptidoglycan Biology RNA Transfer Amino Acyl Biochemistry Article Serine Amino acid biosynthesis chemistry.chemical_compound Membrane Lipids Structural Biology Genetics Protein biosynthesis AA-tRNA Molecular Biology Amino acid synthesis chemistry.chemical_classification Bacteria RNA Proteins Cell Biology Membrane modification Amino acid Anti-Bacterial Agents chemistry Tetrapyrroles Protein Biosynthesis Transfer RNA Antibiotic synthesis |
| Zdroj: | FEBS Letters. (2):366-375 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2009.11.045 |
| Popis: | During protein synthesis, tRNA serves as the intermediary between cognate amino acids and their corresponding RNA trinucleotide codons. Aminoacyl-tRNA is also a biosynthetic precursor and amino acid donor for other macromolecules. AA-tRNAs allow transformations of acidic amino acids into their amide-containing counterparts, and seryl-tRNASer donates serine for antibiotic synthesis. Aminoacyl-tRNA is also used to cross-link peptidoglycan, to lysinylate the lipid bilayer, and to allow proteolytic turnover via the N-end rule. These alternative functions may signal the use of RNA in early evolution as both a biological scaffold and a catalyst to achieve a wide variety of chemical transformations. |
| Databáze: | OpenAIRE |
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