Prediction of preterm birth in multiple pregnancies
| Autor: | Lidewij van de Mheen, Hein W. Bruinse, Jan Jaap H. M. Erwich, Martina Porath, Johannes J. Duvekot, Tom H.M. Hasaart, Ben W.J. Mol, Rolf H.H. Groenwold, Ewoud Schuit, Arianne C. Lim, Piet Hummel, Charlotte M. van Oirschot, Maria G. van Pampus, Christianne J.M. de Groot, K Moons, Dimitri N.M. Papatsonis, Jim van Eyck |
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| Přispěvatelé: | Other departments, APH - Amsterdam Public Health, Other Research, Obstetrics and Gynaecology, Obstetrics and gynaecology, ICaR - Ischemia and repair, Public Health, Obstetrics & Gynecology, Reproductive Origins of Adult Health and Disease (ROAHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis Gestational Age law.invention Randomized controlled trial law Pregnancy medicine Humans business.industry Proportional hazards model Obstetrics Smoking Obstetrics and Gynecology Gestational age medicine.disease Cervical Length Measurement Premature birth Multivariate Analysis Gestation Educational Status Premature Birth Female Pregnancy Multiple business Multiple |
| Zdroj: | van de Mheen, L, Schuit, E, Lim, A C, Porath, M M, Papatsonis, D, Erwich, J J, van Eyck, J, van Oirschot, C M, Hummel, P, Duvekot, J J, Hasaart, T H M, Groenwold, R H H, Moons, K G M, de Groot, C J M, Bruinse, H W, van Pampus, M G & Mol, B W J 2014, ' Prediction of preterm birth in multiple pregnancies: development of a multivariable model including cervical length measurement at 16 to 21 weeks' gestation ', Journal of obstetrics and gynaecology Canada, vol. 36, no. 4, pp. 309-319 . < http://www.researchgate.net/profile/Ewoud_Schuit/publication/262075807_Prediction_of_preterm_birth_in_multiple_pregnancies_development_of_a_multivariable_model_including_cervical_length_measurement_at_16_to_21_weeks%27_gestation/links/53f1b9e10cf23733e815cf9a.pdf > Journal of obstetrics and gynaecology Canada : JOGC = Journal d obstetrique et gynecologie du Canada, 36(4), 309-319. Healthcare & Financial Pub. Journal of obstetrics and gynaecology Canada, 36(4), 309-319. Healthcare & Financial Pub. JOGC. Journal of Obstetrics and Gynaecology (Canada), 36(4), 309-319. Elsevier Inc. Journal of Obstetrics and Gynaecology Canada, 36(4), 309-19 |
| ISSN: | 1701-2163 |
| DOI: | 10.1016/S1701-2163(15)30606-X |
| Popis: | OBJECTIVE: To develop a multivariable prognostic model for the risk of preterm delivery in women with multiple pregnancy that includes cervical length measurement at 16 to 21 weeks' gestation and other variables.METHODS: We used data from a previous randomized trial. We assessed the association between maternal and pregnancy characteristics including cervical length measurement at 16 to 21 weeks' gestation and time to delivery using multivariable Cox regression modelling. Performance of the final model was assessed for the outcomes of preterm and very preterm delivery using calibration and discrimination measures.RESULTS: We studied 507 women, of whom 270 (53%) delivered < 37 weeks (preterm) and 66 (13%) < 32 weeks (very preterm). Women with cervical length < 30 mm delivered more often preterm (hazard ratio 1.9; 95% CI 0.7 to 4.8). Other independently contributing predictors were previous preterm delivery, monochorionicity, smoking, educational level, and triplet pregnancy. Prediction models for preterm and very preterm delivery had a c-index of 0.68 (95% CI 0.63 to 0.72) and 0.68 (95% CI 0.62 to 0.75), respectively, and showed good calibration.CONCLUSION: In women with a multiple pregnancy, the risk of preterm delivery can be assessed with a multivariable model incorporating cervical length and other predictors. |
| Databáze: | OpenAIRE |
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