Altered L-DOPA Systems for Blood Pressure Regulation in the Lower Brainstem of Spontaneously Hypertensive Rats
| Autor: | Takeaki Miyamae, Yoshimi Misu, Yoshio Goshima, Jin-Liang Yue |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Baroreceptor Physiology Blood Pressure Rats Inbred WKY Levodopa chemistry.chemical_compound Postsynaptic potential Rats Inbred SHR Internal medicine Internal Medicine medicine Animals Neurotransmitter Medulla business.industry musculoskeletal neural and ocular physiology Rostral ventrolateral medulla Baroreflex Rats Blood pressure Endocrinology medicine.anatomical_structure nervous system chemistry Anesthesia Hypertension cardiovascular system Brainstem Cardiology and Cardiovascular Medicine business Nucleus Brain Stem circulatory and respiratory physiology |
| Zdroj: | Hypertension Research. 18:267-277 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.18.267 |
| Popis: | Recent findings have enhanced our understanding of the roles played by the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the lower brainstem. L-DOPA is probably a neurotransmitter of primary baroreceptor afferents terminating in depressor sites of the nucleus tractus solitarii (NTS). It also seems to be a neurotransmitter in depressor sites of the caudal ventrolateral medulla (CVLM) and in pressor sites of the rostral ventrolateral medulla (RVLM) of normotensive Wistar rats. We have explored whether or not presynaptic and postsynaptic functions of the L-DOPA system in these areas are altered to maintain hypertension in adult spontaneously hypertensive rats, as compared with age-matched Wistar Kyoto rats. In this review article, we survey the roles of the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the rat lower brainstem. (Hypertens Res 1995; 18: 267-277) |
| Databáze: | OpenAIRE |
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