Revascularization of human ovarian grafts is equally efficient from both sides of the cortex tissue
| Autor: | Stine G. Kristensen, Hanna Ø. Olesen, Mette C. Zeuthen, Susanne E. Pors, Claus Y. Andersen, Linn S. Mamsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Kristensen, S G, Olesen, H Ø, Zeuthen, M C, Pors, S E, Andersen, C Y & Mamsen, L S 2022, ' Revascularization of human ovarian grafts is equally efficient from both sides of the cortex tissue ', Reproductive BioMedicine Online, vol. 44, no. 6, pp. 991-994 . https://doi.org/10.1016/j.rbmo.2022.02.009 |
| Popis: | Does revascularization of human ovarian grafts in a mouse model occur with equal efficiency from both sides of the cortex tissue?Twenty-four frozen-thawed ovarian cortex pieces from 12 women were transplanted to immunodeficient mice, for 8 days to analyse graft revascularization using immunohistochemical detection of murine CD31, or for 8 weeks to evaluate follicle density (follicles/mmNo significant difference in the mean percentage of the CD31-positive vessel area was found between the three ROI (cortical side: 3.9% ± 0.2%; centre: 3.5% ± 0.2%; medullary side: 4.0% ± 0.3%; P = 0.17), but a significantly lower density of vessels was found in the centre of the human ovarian grafts compared with the cortical and medullary sides (cortical side: 323 ± 14 vessels/mmHost revascularization was established equally efficiently from both sides of transplanted human ovarian cortex, suggesting that transplantation techniques ensuring revascularization from both sides of the ovarian graft could potentially facilitate faster graft revascularization. |
| Databáze: | OpenAIRE |
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