Psychometric, Polysomnographic, and Neuroendocrine Measures in Subjects at High Risk for Psychiatric Disorders: Preliminary Results
| Autor: | Jürgen-Christian Krieg, Christoph J. Lauer, Florian Holsboer, Leo Hermle, Thomas Pollmächer, U von Bardeleben |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Cortisol secretion medicine.medical_specialty Hydrocortisone Psychometrics Corticotropin-Releasing Hormone media_common.quotation_subject Neuroendocrinology Dexamethasone Predictive Value of Tests medicine Humans Personality Longitudinal Studies Psychiatry Biological Psychiatry media_common Psychiatric Status Rating Scales Mental Disorders Electroencephalography Neuroticism Psychiatry and Mental health Neuropsychology and Physiological Psychology Female Sleep Psychology Psychopathology medicine.drug Vigilance (psychology) |
| Zdroj: | Neuropsychobiology. 23:57-67 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000119428 |
| Popis: | We report on the psychometric, polysomnographic, and neuroendocrine status of 12 subjects at high familial risk for psychiatric disorders and of 10 healthy subjects not at high risk. The psychometric measurements in the high-risk probands revealed an accentuated 'stress personality' pattern and an increased neuroticism score. Their all-night EEG sleep tended to be shallower than that of the control subjects (i.e., decreased sleep efficiency, more frequent awakenings, less slow-wave sleep), whereas they did not differ on REM sleep parameters. The challenge of the limbic-hypothalamic-pituitary-adrenocortical system with corticotropin-releasing hormone after pretreatment with dexamethasone yielded no differences in cortisol secretion between the groups. On an intraindividual level, however, all subjects at high risk except one were found to be conspicuous in at least one of the three states examined. |
| Databáze: | OpenAIRE |
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