A pro longevity role for cellular senescence
| Autor: | Veronica Cocchi, Amany Attaallah, Monia Lenzi, Silvana Hrelia, Antonello Lorenzini, Silvia Marchionni, Eleonora Croco, Christian Sell, Patrizia Hrelia, Giacomo Bincoletto |
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| Přispěvatelé: | Amany Attaallah, Monia Lenzi, Silvia Marchionni, Giacomo Bincoletto, Veronica Cocchi, Eleonora Croco, Patrizia Hrelia, Silvana Hrelia, Christian Sell, Antonello Lorenzini |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Senescence
Aging education.field_of_study Cell cycle checkpoint DNA damage media_common.quotation_subject SA β-gal Population Longevity Apoptosi Cell cycle Biology beta-Galactosidase Cellular senescence Molecular medicine Cell biology Apoptosis Animals Original Article Body ma Geriatrics and Gerontology education DNA Damage media_common |
| Zdroj: | GeroScience |
| Popis: | Cellular senescence is a fundamental process that may play positive or detrimental roles for the organism. It is involved in tissue development and in tumor prevention although during aging is becoming a detrimental process contributing to the decline of tissue functions. In previous investigations, we have uncovered a better capacity to detect DNA damage in cells from long-lived mammals. Here, we report that cultured cells derived from long-lived species have a higher propensity to undergo senescence when challenged with DNA damage than cells derived from short-lived species. Using a panel of cells derived from six mammals, which range in lifespan from 3-4 years up to 120 years, we examined cell cycle response, induction of apoptosis and of cellular senescence. All species exhibited a cell cycle arrest while induction of apoptosis was variable. However, a significant positive correlation was found between the relative percent of cells, within a population which entered senescence following damage, and the lifespan of the species. We suggest that cellular senescence may have a positive role during development allowing it to contribute to the evolution of longevity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11357-019-00066-2) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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