Circulating amino acids and the risk of macrovascular, microvascular, and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE trial
| Autor: | Naomi Rankin, Neil Poulter, Michel Marre, Mika Ala-Korpela, Peter Würtz, Patrick B. Mark, P. Hamet, Qiang Li, Mark Woodward, Naveed Sattar, John Chalmers, Paul Welsh |
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| Přispěvatelé: | Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Time Factors Endocrinology Diabetes and Metabolism Type 2 diabetes 030204 cardiovascular system & hematology Gastroenterology METABOLITES DISEASE 0302 clinical medicine Diabetes complications 1114 Paediatrics And Reproductive Medicine EPIDEMIOLOGY Diabetic Nephropathies Amino Acids POPULATION Macrovascular disease education.field_of_study INSULIN-RESISTANCE Framingham Risk Score PHENYLALANINE ASSOCIATION Middle Aged Prognosis 3. Good health Amino acid 1117 Public Health And Health Services Female medicine.medical_specialty Population Lower risk Risk Assessment Article Nephropathy 03 medical and health sciences Endocrinology & Metabolism Insulin resistance MAGNETIC-RESONANCE METABOLOMICS Predictive Value of Tests Internal medicine Diabetes mellitus Internal Medicine medicine Humans Metabolomics education Aged Diabetic Retinopathy business.industry 1103 Clinical Sciences PROFILES medicine.disease BRANCHED-CHAIN 030104 developmental biology Diabetes Mellitus Type 2 Risk factors 3121 General medicine internal medicine and other clinical medicine business Biomarkers |
| Zdroj: | Welsh, P, Rankin, N, Li, Q, Mark, P B, Würtz, P, Ala-Korpela, M, Marre, M, Poulter, N, Hamet, P, Chalmers, J, Woodward, M & Sattar, N 2018, ' Circulating amino acids and the risk of macrovascular, microvascular and mortality outcomes in individuals with type 2 diabetes : results from the ADVANCE trial ', Diabetologia, vol. 61, no. 7, pp. 1581-1591 . https://doi.org/10.1007/s00125-018-4619-x Diabetologia |
| ISSN: | 0012-186X |
| Popis: | Aims/hypotheses We aimed to quantify the association of individual circulating amino acids with macrovascular disease, microvascular disease and all-cause mortality in individuals with type 2 diabetes. Methods We performed a case-cohort study (N = 3587), including 655 macrovascular events, 342 microvascular events (new or worsening nephropathy or retinopathy) and 632 all-cause mortality events during follow-up, in a secondary analysis of the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) study. For this study, phenylalanine, isoleucine, glutamine, leucine, alanine, tyrosine, histidine and valine were measured in stored plasma samples by proton NMR metabolomics. Hazard ratios were modelled per SD increase in each amino acid. Results In models investigating associations and potential mechanisms, after adjusting for age, sex and randomised treatment, phenylalanine was positively, and histidine inversely, associated with macrovascular disease risk. These associations were attenuated to the null on further adjustment for extended classical risk factors (including eGFR and urinary albumin/creatinine ratio). After adjustment for extended classical risk factors, higher tyrosine and alanine levels were associated with decreased risk of microvascular disease (HR 0.78; 95% CI 0.67, 0.91 and HR 0.86; 95% CI 0.76, 0.98, respectively). Higher leucine (HR 0.79; 95% CI 0.69, 0.90), histidine (HR 0.89; 95% CI 0.81, 0.99) and valine (HR 0.79; 95% CI 0.70, 0.88) levels were associated with lower risk of mortality. Investigating the predictive ability of amino acids, addition of all amino acids to a risk score modestly improved classification of participants for macrovascular (continuous net reclassification index [NRI] +35.5%, p |
| Databáze: | OpenAIRE |
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