Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions
| Autor: | Rosa Gini, Ltw de Jong-van den Berg, Aurora Puccini, Ester Garne, HJ Bos, Daniel Thayer, Amanda J. Neville, Anne Vinkel Hansen, Helen Dolk, Anna Pierini, Rachel Charlton, A M Nybo Andersen, Karen Tingay, Sue Jordan, Marlene Sinclair |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty PRESCRIPTION Serotonin reuptake inhibitor Denmark Population DRUG-USE MEDICATION USE Health care medicine Humans Drug utilisation Medical prescription Practice Patterns Physicians' serotonin uptake inhibitors education Depression (differential diagnoses) METAANALYSIS Netherlands RISK education.field_of_study Pregnancy Depressive Disorder business.industry Obstetrics and Gynecology WOMEN medicine.disease DEPRESSION Paroxetine Confidence interval United Kingdom 3. Good health PERSISTENT PULMONARY-HYPERTENSION PREVALENCE Pregnancy Complications electronic health records Italy PATTERNS Female pregnancy business Selective Serotonin Reuptake Inhibitors Demography medicine.drug |
| Zdroj: | Charlton, R A, Jordan, S, Pierini, A, Garne, E, Neville, A J, Hansen, A V, Gini, R, Thayer, D, Tingay, K, Puccini, A, Bos, H J, Nybo Andersen, A M, Sinclair, M, Dolk, H & De Jong-Van Den Berg, L T W 2015, ' Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy : a population-based study in six European regions ', BJOG : An International Journal Of Obstetrics & Gynaecology, vol. 122, no. 7, pp. 1010-1020 . https://doi.org/10.1111/1471-0528.13143 BJOG : An International Journal of Obstetrics and Gynaecology, 122(7), 1010-1020. Wiley Charlton, R, Jordan, S, Pierini, A, Garne, E, Neville, A, Hansen, A, Gini, R, Thayer, D, Tingay, K, Puccini, A, Bos, H, Nybo Andersen, A, Sinclair, M, Dolk, H & de Jong-van den Berg, L 2015, ' Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population-based study in six European regions ', B J O G, vol. 122, no. 7, pp. 1010–1020 . https://doi.org/10.1111/1471-0528.13143 |
| ISSN: | 1471-0528 |
| DOI: | 10.1111/1471-0528.13143 |
| Popis: | Objective To explore the prescribing patterns of selective serotonin reuptake inhibitors (SSRIs) before, during and after pregnancy in six European population-based databases. Design Descriptive drug utilisation study. Setting Six electronic healthcare databases in Denmark, the Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK. Population All women with a pregnancy ending in a live or stillbirth starting and ending between 2004 and 2010. Methods A common protocol was implemented across databases to identify SSRI prescriptions issued (UK) or dispensed (non-UK) in the year before, during or in the year following pregnancy. Main outcome measures The percentage of deliveries in which the woman received an SSRI prescription in the year before, during or in the year following pregnancy. We also compared the choice of SSRIs and changes in prescribing over the study period. Results In total, 721 632 women and 862 943 deliveries were identified. In the year preceding pregnancy, the prevalence of SSRI prescribing was highest in Wales [9.6%; 95% confidence interval (CI95), 9.4-9.8%] and lowest in Emilia Romagna (3.3%; CI95, 3.2-3.4%). During pregnancy, SSRI prescribing had dropped to between 1.2% (CI95, 1.1-1.3%) in Emilia Romagna and 4.5% (CI95, 4.3-4.6%) in Wales. The higher UK pre-pregnancy prescribing rates resulted in higher first trimester exposures. After pregnancy, SSRI prescribing increased most rapidly in the UK. Paroxetine was more commonly prescribed in the Netherlands and Italian regions than in Denmark and the UK. Conclusions The higher SSRI prescribing rates in the UK, compared with other European regions, raise questions about differences in the prevalence and severity of depression and its management in pregnancy across Europe. |
| Databáze: | OpenAIRE |
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