Entropy and uniformity as additional parameters to optimize the effectiveness of bone CT in the evaluation of acromegalic patients
| Autor: | Pedro de Azevedo Berger, Bernardo Alves Barbosa, Márcio Garrison Dytz, Wagner Diniz de Paula, Luciana Ansaneli Naves, Armindo Jreige Junior, Olga de Castro Dytz, Neysa Aparecida Tinoco Reggatieri, Arthur Disegna, Luiz Augusto Casulari |
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| Rok vydání: | 2019 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Entropy Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Absorptiometry Photon Region of interest Bone Density Diabetes mellitus Acromegaly Medicine Humans Femoral neck Bone mineral Lumbar Vertebrae business.industry medicine.disease medicine.anatomical_structure Cross-Sectional Studies 030220 oncology & carcinogenesis Lumbar spine Secondary osteoporosis business Nuclear medicine Tomography X-Ray Computed |
| Zdroj: | Endocrine. 69(2) |
| ISSN: | 1559-0100 |
| Popis: | Acromegaly is considered an important cause of secondary osteoporosis. However, studies on bone mineral density (BMD) have yielded conflicting results and there are few studies that evaluate an accurate imaging method for early diagnosis of osteoporosis in these patients. The objective of this study was to assess whether entropy and uniformity on computed tomography (CT) scans are useful parameters for optimization of assessment of bone fragility in patients with acromegaly. We included 34 patients and 36 controls matched for age and sex in a cross-sectional study. Patients and controls underwent CT scan of the lumbosacral spine, dual-energy x-ray absorptiometry (DXA) and blood tests. A software was developed to calculate the entropy and uniformity by a region of interest (ROI) of the trabecular bone of the first lumbar vertebra (L1). The acromegalic group presented higher mean bone entropy (6.87 ± 0.98 vs. 6.03 ± 1.68, p = 0.013) and lower mean bone uniformity (0.035 ± 0.704 vs. 0.113 ± 0.205, p = 0.035) than control group. Analyzing only acromegalics, mean bone entropy was higher and bone uniformity was lower in patients with hypogonadism than patients without hypogonadism (7.28 ± 0.36 vs. 6.74 ± 1.08, p = 0.038 and 0.008 ± 0.002 vs. 0.043 ± 0.079, p = 0.031) respectively. Patients with acromegaly presented higher BMD and Z-score in the femoral neck than control group (1.156 ± 0.108 vs. 0.925 ± 0.326 g/cm2, p = 0.043 and 0.6 ± 0.6 vs. −0.05 ± 0.8, p = 0.041, respectively). Entropy was negatively correlated with T-score of the lumbar spine (rp = −0.357, p = 0.033) in control group and uniformity was positively correlated with T-score of the lumbar spine, neck, and total hip, respectively (rp = 0.371, p = 0.031; rp = 0.348, p = 0.043 and rp = 0.341, p = 0.049) in acromegalic group. The study identified that entropy and uniformity are a relevant parameters data in bone fragility assessment in acromegalic patients. |
| Databáze: | OpenAIRE |
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