Physical limits to biomechanical sensing in disordered fibre networks
| Autor: | Stefan Münster, Farzan Beroz, Chase P. Broedersz, David A. Weitz, Louise Jawerth, Ned S. Wingreen |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Materials science animal structures Generic property Science General Physics and Astronomy Fiber network Nanotechnology Mechanotransduction Cellular Models Biological Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Position (vector) medicine Humans Scaling Fibrin Multidisciplinary technology industry and agriculture Stiffness General Chemistry Elastic Tissue equipment and supplies Elasticity Extracellular Matrix Living matter 030104 developmental biology Collagen medicine.symptom Tissue stiffness Biological system |
| Zdroj: | Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| Popis: | Cells actively probe and respond to the stiffness of their surroundings. Since mechanosensory cells in connective tissue are surrounded by a disordered network of biopolymers, their in vivo mechanical environment can be extremely heterogeneous. Here we investigate how this heterogeneity impacts mechanosensing by modelling the cell as an idealized local stiffness sensor inside a disordered fibre network. For all types of networks we study, including experimentally-imaged collagen and fibrin architectures, we find that measurements applied at different points yield a strikingly broad range of local stiffnesses, spanning roughly two decades. We verify via simulations and scaling arguments that this broad range of local stiffnesses is a generic property of disordered fibre networks. Finally, we show that to obtain optimal, reliable estimates of global tissue stiffness, a cell must adjust its size, shape, and position to integrate multiple stiffness measurements over extended regions of space. Cells in the connective tissue are surrounded by a heterogeneous network of biopolymers. Here, the authors investigate how such heterogeneity affects cellular mechanosensing by simulating the deformation response of experimental and modelled biopolymer networks to locally applied forces. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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