Target identification of biologically active small molecules via in situ methods

Autor:	Biwei Zhu, Shao Q. Yao, Jingyan Ge, Yuguo Zheng, Qing Zhu, Ying Su
Rok vydání:	2013
Předmět:	In situ Proteomics Proteome Drug discovery Cell Survival Biological activity Nanotechnology Computational biology Biology Biochemistry Small molecule Analytical Chemistry Off targets Small Molecule Libraries Drug Design Humans Identification (biology)
Zdroj:	Current opinion in chemical biology. 17(5)
ISSN:	1879-0402
Popis:	The identification of potential cellular targets of small molecules is important in biomedical research and drug discovery, but has been challenging due to a lack of proteome-based methods that enable direct investigation of small molecule-protein interaction in live cells. This review summarizes some of the recent advances in target identification of bioactive molecules (including drugs and natural products) using in situ methods for cell-based proteome profiling of potential on and off targets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ddebea53141d1ca2d6b65c4bef4644 https://pubmed.ncbi.nlm.nih.gov/23796909 Zobrazit plný text záznamu Full Text from ScienceDirect