Physicochemical Compatibility of Dexmedetomidine With Parenteral Nutrition
| Autor: | Joana Cardenete, Noe Garin, Ylenia Campos-Baeta, Daniel Cardona, Mar Saavedra-Mitjans, Pau Riera |
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| Rok vydání: | 2019 |
| Předmět: |
Parenteral Nutrition
Critical Care 030309 nutrition & dietetics Drug Storage Medicine (miscellaneous) pH meter Drug Incompatibility 03 medical and health sciences 0302 clinical medicine Drug Stability Intensive care Sedative agent medicine Adrenergic alpha-2 Receptor Agonists Humans Dexmedetomidine Infusions Intravenous 0303 health sciences Parenteral Nutrition Solutions Nutrition and Dietetics Chromatography business.industry Weight range Parenteral nutrition Pharmaceutical Preparations Fat Droplet 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral NutritionReferences. 35(5) |
| ISSN: | 1941-2452 |
| Popis: | Background Dexmedetomidine is an α2-agonist used as a sedative agent in the intensive care setting. Simultaneous administration of dexmedetomidine and parenteral nutrition (PN) may be required. The aim of this study was to evaluate the physicochemical compatibility of dexmedetomidine Y-site administered with PN. Methods Three PN and 3 dexmedetomidine solutions were compounded. The tested infusion rate for PN was 66 mL/h. For dexmedetomidine, we considered the initial and maximum infusion rates (0.7 and 1.4 µg/kg/h) detailed in the data sheet. Taking this into account and considering a weight range of 55-95 kg, we tested 2 dexmedetomidine infusion rates (10 and 36 mL/h). The samples obtained were examined visually against light. pH was analyzed with a pH meter. Mean fat droplet diameter was determined by dynamic light scattering. Quantification of dexmedetomidine concentration was carried out by ultraperformance liquid chromatography-high-resolution mass spectrometry. For each PN-dexmedetomidine admixture, tests were performed in triplicate. Results No alterations were observed by visual inspection. Average pH was 6.25 ± 0.01. Droplet diameter remained below 500 nm (298 ± 10 nm for 10-mL/h rate and 303 ± 5 nm for 36-mL/h rate). Dexmedetomidine concentrations at t = 0 were 519 ± 31 ng/mL and 1391 ± 90 ng/mL for 10- and 36-mL/h infusion rates, respectively. At t = 24 hours, the concentrations obtained were 494 ± 22 and 1332 ± 102 ng/mL, which translates into ≥90% of the initial concentrations. Conclusion Dexmedetomidine is physicochemically compatible with PN during simulated Y-site administration at the tested infusion rates. |
| Databáze: | OpenAIRE |
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