Highly Hydrophilic Gold Nanoparticles as Carrier for Anticancer Copper(I) Complexes: Loading and Release Studies for Biomedical Applications
| Autor: | M. Porchia, Laura Carlini, Francesco Tisato, Maura Pellei, Iole Venditti, Chiara Battocchio, Elena Magnano, Federica Bondino, Ilaria Fratoddi, Simone Amatori, Carlo Santini |
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| Přispěvatelé: | Fratoddi, Ilaria, Venditti, Iole, Battocchio, Chiara, Carlini, Laura, Amatori, Simone, Porchia, Marina, Tisato, Francesco, Bondino, Federica, Magnano, Elena, Pellei, Maura, Santini, Carlo |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
conjugates
General Chemical Engineering gold nanoparticles copper(I) complexes drug delivery anticancer compounds 02 engineering and technology Conjugated system 010402 general chemistry 01 natural sciences Article lcsh:Chemistry chemistry.chemical_compound Dynamic light scattering Moiety General Materials Science Homoleptic Cationic polymerization copper (I) complexes 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences 3. Good health chemistry lcsh:QD1-999 Colloidal gold Drug delivery 0210 nano-technology Nuclear chemistry |
| Zdroj: | Nanomaterials, Vol 9, Iss 5, p 772 (2019) Nanomaterials (Basel) 9 (2019): 772–785. doi:10.3390/nano9050772 info:cnr-pdr/source/autori:Fratoddi I.; Venditti I.; Battocchio C.; Carlini L.; Amatori S.; Porchia M:; Tisato F.; Bondino F.; Magnano A:; Pellei M.; Santini C./titolo:Highly Hydrophilic Gold Nanoparticles as Carrier for Anticancer Copper(I) Complexes: Loading and Release Studies for Biomedical Applications/doi:10.3390%2Fnano9050772/rivista:Nanomaterials (Basel)/anno:2019/pagina_da:772/pagina_a:785/intervallo_pagine:772–785/volume:9 Nanomaterials Volume 9 Issue 5 |
| ISSN: | 2079-4991 |
| Popis: | Gold nanoparticles (AuNPs), which are strongly hydrophilic and dimensionally suitable for drug delivery, were used in loading and release studies of two different copper(I)-based antitumor complexes, namely [Cu(PTA)4]+ [BF4]&minus (A PTA = 1, 3, 5-triaza-7-phosphadamantane) and [HB(pz)3Cu(PCN)] (B HB(pz)3 = tris(pyrazolyl)borate, PCN = tris(cyanoethyl)phosphane). In the homoleptic, water-soluble compound A, the metal is tetrahedrally arranged in a cationic moiety. Compound B is instead a mixed-ligand (scorpionate/phosphane), neutral complex insoluble in water. In this work, the loading procedures and the loading efficiency of A and B complexes on the AuNPs were investigated, with the aim to improve their bioavailability and to obtain a controlled release. The non-covalent interactions of A and B with the AuNPs surface were studied by means of dynamic light scattering (DLS), UV&ndash Vis, FT-IR and high-resolution x-ray photoelectron spectroscopy (HR-XPS) measurements. As a result, the AuNPs-A system proved to be more stable and efficient than the AuNPs-B system. In fact, for AuNPs-A the drug loading reached 90%, whereas for AuNPs-B it reached 65%. For AuNPs-A conjugated systems, a release study in water solution was performed over 4 days, showing a slow release up to 10%. |
| Databáze: | OpenAIRE |
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