Effects of food on oxaprozin bioavailability
| Autor: | Soong T. Chiang, John Knowles, Hans W. Ruelius, Barry R. Walker, Jerome A. Hubsher |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Cmax Anti-Inflammatory Agents Biological Availability Oral administration Internal medicine Oxaprozin medicine Ingestion Humans Pharmacology (medical) Volunteer Pharmacology business.industry Fasting Crossover study Bioavailability Kinetics Postprandial Endocrinology Food Propionates business medicine.drug |
| Zdroj: | Journal of clinical pharmacology. 24(8-9) |
| ISSN: | 0091-2700 |
| Popis: | Twelve healthy volunteers received single 1200-mg oral doses of oxaprozin while fasting and immediately after a standard breakfast in a two-period crossover design with three weeks between administrations. Oxaprozin plasma concentrations were monitored during a 10-day period after each dose. No statistically significant differences were noted between kinetic parameters obtained in the fasting and post-prandial states for mean peak plasma concentrations (Cmax, 103 vs. 109 micrograms/ml), absorption rate constants (ka, 1.1 vs. 0.8 h-1), or total AUC (7042 vs. 7066 micrograms/ml X hr). Compared with doses administered during fasting, postprandial doses led to a delay in the onset of absorption in the gastrointestinal tract (lag time t0, 24 vs. 9 min), but not in the peak time (tmax approximately 5 hours). Oxaprozin's mean residence time t was slightly shorter for subjects in the postprandial state (72 hours) than for those in fasting state (73 hours), probably because of the intrasubject variability in half-life (48 vs. 50 hours). The results of this study indicate that the ingestion of food has no effect on the bioavailability of oxaprozin. |
| Databáze: | OpenAIRE |
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