Neuromuscular action of crotalid venom: preliminar data

Autor: Maria Dorvalina da Silva, Benedito Barraviera, Rinaldo Poncio Mendes, Luiz Antonio de Lima Resende, Anete Kimuni Ueda, M. R. Montenegro
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Jazyk: portugalština
Rok vydání: 1996
Předmět:
Zdroj: Arquivos de Neuro-Psiquiatria v.54 n.1 1996
Arquivos de neuro-psiquiatria
Academia Brasileira de Neurologia
instacron:ABNEURO
SciELO
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0004-282X
Popis: Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:47:42Z No. of bitstreams: 1 S0004-282X1996000100001.pdf: 1178103 bytes, checksum: a4d1872a98f84c6e948f4e34f254bf64 (MD5) Made available in DSpace on 2013-08-22T18:47:42Z (GMT). No. of bitstreams: 1 S0004-282X1996000100001.pdf: 1178103 bytes, checksum: a4d1872a98f84c6e948f4e34f254bf64 (MD5) Previous issue date: 1996-03-01 Made available in DSpace on 2013-09-30T18:23:14Z (GMT). No. of bitstreams: 2 S0004-282X1996000100001.pdf: 1178103 bytes, checksum: a4d1872a98f84c6e948f4e34f254bf64 (MD5) S0004-282X1996000100001.pdf.txt: 21641 bytes, checksum: f897b90596564f20857ab8cb23add666 (MD5) Previous issue date: 1996-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:37:46Z No. of bitstreams: 2 S0004-282X1996000100001.pdf: 1178103 bytes, checksum: a4d1872a98f84c6e948f4e34f254bf64 (MD5) S0004-282X1996000100001.pdf.txt: 21641 bytes, checksum: f897b90596564f20857ab8cb23add666 (MD5) Made available in DSpace on 2014-05-20T13:37:46Z (GMT). No. of bitstreams: 2 S0004-282X1996000100001.pdf: 1178103 bytes, checksum: a4d1872a98f84c6e948f4e34f254bf64 (MD5) S0004-282X1996000100001.pdf.txt: 21641 bytes, checksum: f897b90596564f20857ab8cb23add666 (MD5) Previous issue date: 1996-03-01 Estudamos 6 pacientes, 2 cães e um coelho com intoxicação crotálica. Avaliamos a condução nervosa periférica sensitiva e motora, a transmissão neuromuscular e eletromiografias. As biópsias de músculo foram processadas por histoquímica. Os 6 pacientes apresentaram mononeuropatia sensitiva no nervo periférico adjacente ao local da inoculação do veneno e encontramos evidências histoquímicas de miopatia mitocondrial. Os defeitos da transmissão neuromuscular foram mínimos. A maioria dos autores admite que veneno crotálico determina síndrome miastênica. Nossos achados indicam que ptose palpebral, facies miastênico e fraqueza muscular observados após acidente crotálico, correspondem provavelmente a miopatia mitocondrial, muitas vezes transitória e reversível. We studied 6 patients and 2 dogs that have been bitten by South American rattlesnake Crotalus durissus terrificus and one rabbit inoculated with crotalid venom. We analized sensory and motor peripheral nerve conduction, repetitive stimulation for studying neuromuscular transmission and electromyographies. Muscle biopsies were processed by histochemistry. All patients had peripheral mononeuropathy of the closest sensitive nerve to the area of snakebite. The neuromuscular transmission alterations were minimal. Muscle histochemistry of 4 patients, 2 dogs and 1 rabbit showed findings of mitochondrial myopathy. The majority of authors admit that crotalid venom causes myastenic syndrome. Our findings suggest that palpebral ptosis, myastenic facies and muscular weakness observed after crotalid poisoning are, probably, due to transient and reversible mitochondrial myopathy. As far as we know, this is the first report on the ability of the venom of this rattlesnake to cause local sensitive mononeuropathy and the first muscle histochemistry showing mitochondrial myopathy in humans poisoned by crotalid venom. UNESP Faculdade de Medicina de Botucatu Departamentos de Neurologia, Moléstias Infecciosas e Patologia UNESP Faculdade de Medicina de Botucatu Departamentos de Neurologia, Moléstias Infecciosas e Patologia
Databáze: OpenAIRE
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