Bone plasticity in response to exercise is sex-dependent in rats
| Autor: | Tatiana L. Fonseca, Charles Chenwei Wang, Vanda Jorgetti, Luciene M. dos Reis, Fabiana G. Graciolli, Rafael G. Graciolli, Wagner S. Vicente, Ana Paula Pereira Velosa, Wagner V. Dominguez, Walcy Rosolia Teodoro, Hamilton Roschel, Bruno Gualano |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Anatomy and Physiology Bone density Gene Expression lcsh:Medicine Biochemistry Bone remodeling Fractures Bone Molecular Cell Biology Biomechanics Femur lcsh:Science Musculoskeletal System Multidisciplinary Physics Bone and Joint Mechanics Animal Models Resorption Isoenzymes Medicine Female Type I collagen Research Article medicine.medical_specialty Bone and Mineral Metabolism Acid Phosphatase Biophysics Biology Osteocytes Collagen Type I Molecular Genetics Model Organisms Sex Factors Rheumatology Hardness Physical Conditioning Animal Internal medicine Genetics medicine Animals RNA Messenger Sports and Exercise Medicine Rats Wistar Bone BIOMECÂNICA Tartrate-Resistant Acid Phosphatase lcsh:R Acid phosphatase Computational Biology Elasticity Rats Sexual dimorphism Apposition Metabolism Endocrinology biology.protein Rat lcsh:Q Biomarkers |
| Zdroj: | PLoS ONE, Vol 8, Iss 5, p e64725 (2013) PLoS ONE Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1932-6203 |
| Popis: | Purpose To characterize the potential sexual dimorphism of bone in response to exercise. Methods Young male and female Wistar rats were either submitted to 12 weeks of exercise or remained sedentary. The training load was adjusted at the mid-trial (week 6) by the maximal speed test. A mechanical test was performed to measure the maximal force, resilience, stiffness, and fracture load. The bone structure, formation, and resorption were obtained by histomorphometric analyses. Type I collagen (COL I) mRNA expression and tartrate-resistant acid phosphatase (TRAP) mRNA expression were evaluated by quantitative real-time PCR (qPCR). Results The male and female trained rats significantly improved their maximum speed during the maximal exercise test (main effect of training; p |
| Databáze: | OpenAIRE |
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