Histone H3.3 G34-mutant Diffuse Gliomas in Adults
| Autor: | Hainan Li, Wei Wang, Ye Cheng, Leiming Wang, Zejun Duan, Kun Yao, Fuyu Wang, Cheng Zhi, Liwei Shao, Shuangshuang Song, Lianghong Teng, Qiu-Ping Gui, Yue-Shan Piao, De-Hong Lu, Xue-Ling Qi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Adolescent Disease PDGFRA medicine.disease_cause Risk Assessment Pathology and Forensic Medicine Histones Histone H3 Diffuse Glioma Young Adult Risk Factors Internal medicine Glioma medicine Biomarkers Tumor Humans Genetic Predisposition to Disease neoplasms ATRX Retrospective Studies Mutation business.industry Brain Neoplasms Middle Aged medicine.disease Isocitrate Dehydrogenase Progression-Free Survival Phenotype Cohort Surgery Female Anatomy Neoplasm Grading business |
| Zdroj: | The American journal of surgical pathology. 46(2) |
| ISSN: | 1532-0979 |
| Popis: | The characteristics of H3.3 G34-mutant gliomas in adults have yet to be specifically described. Thirty adults with H3.3 G34-mutant diffuse gliomas were retrospectively reviewed for clinical and pathologic information. Molecular profiling using next-generation sequencing was performed in 29 of the 30 H3.3 G34-mutant patients with 1 patient lacking available tumor samples, as well as 82 IDH/H3 wild-type adult diffuse glioma patients. The age at diagnosis of H3.3 G34-mutant diffuse gliomas was significantly younger than IDH/H3 wild-type gliomas (24 vs. 57 y, P |
| Databáze: | OpenAIRE |
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