Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety

Autor: M Belén Suárez-Mier, Emilio García-Prieto, M Luisa Gaspar-Carreño, María Sanjurjo-Sáez, Juan Francisco Márquez-Peiró, M Carmen Martínez-Ortega, Rubén Achau-Muñoz, Piedad López-Sánchez, Federico Gordo-Vidal, Irene Aquerreta-González, Lucas J Fernández-Sánchez, Silvia Manrique-Rodríguez, Elizabeth Lafuente-Cabrero, Esther Bermejo-López, E Domingo-Chiva, Irene Heras-Hidalgo, Marta Valera-Rubio, Noemí Cortés-Rey, Miguel Jiménez-Aguado, Manuel Herrera-Gutiérrez, M Camino Del Río Pisabarro, Ana Herranz-Alonso, Carlos Lamela-Piteira, Cristina Díez-Sáenz, Luis Guerra-Sánchez, M Cruz Martín-Delgado, Pedro Rascado-Sedes, Ignacio Pellín Ariño, M Antonia Cubero-Pérez, Verónica Viera-Rodríguez, M Sagrario Pernia-López, Sara Fox-Carpentieri
Rok vydání: 2020
Předmět:
Zdroj: DRUGS IN R&D
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Drugs in R&D
ISSN: 1179-6901
1174-5886
Popis: Background Intravenous drug administration is associated with potential complications, such as phlebitis. The physiochemical characteristics of the infusate play a very important role in some of these problems. Aim The aim of this study was to standardize the dilutions of intravenous drugs most commonly used in hospitalized adult patients and to characterize their pH, osmolarity and cytotoxic nature to better guide the selection of the most appropriate vascular access. Methods The project was conducted in three phases: (i) standardization of intravenous therapy, which was conducted using a modified double-round Delphi method; (ii) characterization of the dilutions agreed on in the previous phase by means of determining the osmolarity and pH of each of the agreed concentrations, and recording the vesicant nature based on the information in literature; and (iii) algorithm proposal for selecting the most appropriate vascular access, taking into account the information gathered in the previous phases. Results In total, 112 drugs were standardized and 307 different admixtures were assessed for pH, osmolarity and vesicant nature. Of these, 123 admixtures (40%), had osmolarity values >600 mOsm/L, pH < 4 or > 9, or were classified as vesicants. In these cases, selection of the most suitable route of infusion and vascular access device is crucial to minimize the risk of phlebitis-type complications. Conclusions Increasing safety of intravenous therapy should be a priority in the healthcare settings. Knowing the characteristics of drugs to assess the risk involved in their administration related to their physicochemical nature may be useful to guide decision making regarding the most appropriate vascular access and devices.
Databáze: OpenAIRE
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