Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection
| Autor: | Wayne T. Nicholson, Rozalin R. Dickson, Halena M. Gazelka, Joel M. Reid, Susan M. Moeschler, W. Michael Hooten, Tim J. Lamer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Triamcinolone acetonide Time Factors Article Subject Pain medicine Anti-Inflammatory Agents Injections Epidural Triamcinolone Statistics Nonparametric Cohort Studies 03 medical and health sciences Cervical radiculopathy 0302 clinical medicine Lumbar Pharmacokinetics 030202 anesthesiology Medicine Humans Radiculopathy Aged Pain Measurement lcsh:R5-920 business.industry Systemic absorption Middle Aged medicine.disease Anesthesiology and Pain Medicine Neurology Radicular pain Anesthesia Fluoroscopy Cohort Female business lcsh:Medicine (General) 030217 neurology & neurosurgery medicine.drug Research Article |
| Zdroj: | Pain Research and Management, Vol 2018 (2018) Pain Research & Management |
| ISSN: | 1918-1523 1203-6765 |
| Popis: | Background. Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids following injection. The primary objective of this study was to investigate the pharmacokinetics of fluoroscopy-guided cervical epidural-administered triamcinolone acetonide in a cohort of patients with cervical radicular pain seeking treatment in a pain medicine clinic.Methods. The study cohort included eight patients undergoing a fluoroscopically guided C7-T1 interlaminar ESI at a pain medicine specialty clinic. Blood was collected prior to the ESI and on days 1, 2, 4, 6, 8, 14, 21, 28, 35, and 42 following the injection. The sample extract was analyzed by tandem mass spectrometry.Results. The terminal elimination half-life of cervical epidural-administered triamcinolone in a noncompartmental analysis was 219 hours. In the noncompartmental analysis, peak triamcinolone concentrations of 5.4 ng/mL were detected within 22.1 hours after administration.Conclusions. The pharmacokinetics of cervical epidural-administered triamcinolone is consistent with our previous study of lumbar ESI, demonstrating that the elimination half-life is longer than that which has been reported following intravenous triamcinolone. The elimination half-life was shorter following cervical ESI than that which has been reported following lumbar ESI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text