In vivo photoacoustic lipid imaging in mice using the second near-infrared window
Autor: | Evan H. Phillips, Craig J. Goergen, Gurneet S Sangha |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Near-infrared spectroscopy Photoacoustic imaging in biomedicine Magnetic resonance imaging 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Atomic and Molecular Physics and Optics Pathophysiology Article 010309 optics Fat accumulation Positron emission tomography In vivo 0103 physical sciences medicine 0210 nano-technology business Preclinical imaging Biotechnology |
Popis: | Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical imaging by providing users with label-free optical contrast of tissue. Here, we present a proof-of-concept study for noninvasive in vivo murine lipid imaging using 1210 nm light to investigate differences in periaortic fat among mice of different gender, genotypes, and maturation. Acquired lipid signals suggest that adult male apoE-/- mice have greater periaortic fat accumulation compared to adolescent males, apoE-/- females, and wild-type mice. These results demonstrate the potential of photoacoustic tomography for studying vascular pathophysiology and improving the diagnosis of lipid-based diseases. |
Databáze: | OpenAIRE |
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