Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case-series study
| Autor: | Emmanuel Oger, Philippe Bouchard, Edouard Bardou-Jacquet, Vincent Meuric, Emile Boyer, Denis Bourgeois, Martine Bonnaure-Mallet, Fabrice Lainé, Yves Deugnier, Sandrine Le Gall-David, Valérie Turmel |
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| Přispěvatelé: | Jonchère, Laurent, CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), Université Paris Descartes - Paris 5 (UPD5), Université de Rennes 1, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Investigation Clinique [Rennes] ( CIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Nutrition, Métabolismes et Cancer ( NuMeCan ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Pathologies, Imagerie et Biothérapies oro-faciales ( EA 2496 ), Université Paris Descartes - Paris 5 ( UPD5 ) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Dentistry Severe periodontitis Gastroenterology iron burden 03 medical and health sciences 0302 clinical medicine transferrin saturation Internal medicine medicine periodontitis Hemochromatosis [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Periodontitis business.industry Transferrin saturation Medical record 030206 dentistry [ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Hepatology medicine.disease 3. Good health 030104 developmental biology haemochromatosis Periodontics Population study business Case series |
| Zdroj: | Journal of Clinical Periodontology Journal of Clinical Periodontology, 2017, 44 (9), pp.892-897. ⟨10.1111/jcpe.12760⟩ Journal of Clinical Periodontology, Wiley, 2017, 44 (9), pp.892-897. ⟨10.1111/jcpe.12760⟩ Journal of Clinical Periodontology, Wiley, 2017, 44 (9), pp.892-897. 〈10.1111/jcpe.12760〉 |
| ISSN: | 0303-6979 1600-051X |
| DOI: | 10.1111/jcpe.12760 |
| Popis: | International audience; Aim: To investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis.Material and Methods: This clinical case series included 84 HFE-C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated.Results: The study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p =.002).Conclusion: Severe periodontitis is associated with the severity of iron burden in patients with HFE-related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients. © 2017 John Wiley and Sons A/S. Published by John Wiley and Sons Ltd |
| Databáze: | OpenAIRE |
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