Booster vaccination of toddlers with reduced antigen content diphtheria -- tetanus -- acellular pertussis vaccine
| Autor: | Kerry-Ann F. O'Grady, Stephen B. Lambert, Jim Buttery, Terry Nolan, Bernard Hoet, Catherine Streeton, Hans L. Bock, Tilman A Ruff |
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| Rok vydání: | 2008 |
| Předmět: |
animal diseases
Immunization Secondary Booster dose Diphtheria-Tetanus-acellular Pertussis Vaccines complex mixtures Double-Blind Method medicine Humans Single-Blind Method Whooping cough Antigens Bacterial Reactogenicity Booster (rocketry) General Veterinary General Immunology and Microbiology Tetanus business.industry Diphtheria Public Health Environmental and Occupational Health Infant respiratory system medicine.disease Antibodies Bacterial Vaccination Infectious Diseases Immunology cardiovascular system Molecular Medicine business circulatory and respiratory physiology |
| Zdroj: | Vaccine. 27(18) |
| ISSN: | 0264-410X |
| Popis: | Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18 - 20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, and > or = 93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given. |
| Databáze: | OpenAIRE |
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