Isolation and structure determination of a new thiopeptide globimycin from Streptomyces globisporus subsp. globisporus based on genome mining
| Autor: | Issara Kaweewan, Hikaru Hemmi, Shinya Kodani, Hisayuki Komaki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Streptomyces globisporus biology Chemistry Stereochemistry 030106 microbiology Organic Chemistry 010402 general chemistry Isolation (microbiology) biology.organism_classification 01 natural sciences Biochemistry Genome 0104 chemical sciences 03 medical and health sciences Drug Discovery Gene cluster Genome mining Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | SC30201804130022 NARO成果DBd |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2017.12.056 |
| Popis: | Based on genome-mining, a new thiopeptide globimycin was discovered from the extract of Streptomyces globisporus subsp. globisporus, along with known one radamycin. The structure of globimycin was established by a combination of 2D NMR and ESI-MS experiments, and globimycin was identified to be a structural isomer of a known thiopeptide methylsulfomycin. The proposed biosynthetic gene cluster for globimycin and radamycin was found in the genome of S. globisporus subsp. globisporus. |
| Databáze: | OpenAIRE |
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