Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004
| Autor: | Luc Taillandier, Chantal Campello, Pascale Fabbro-Peray, Michel Wager, Brigitte Trétarre, Christine Kerr, Jérôme Honnorat, Jean-Pierre Daurès, Aline Schlama, François Labrousse, Luc Bauchet, Hugues Loiseau, Didier Frappaz, Karl Lainé, Fabienne Bauchet, Maria Cristina Patru, Philippe Menei, Dominique Figarella-Branger, Monique Reme-Saumon, Michel Fabbro, Valérie Rigau, Dominique Henin, Thierry Faillot, Laurent Capelle, Hugues Duffau, Hélène Mathieu-Daudé, Olivier Chinot, Martine Lionnet, Lorelei Pallusseau, Charlotte Carnin, Agnes Thiebaut |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Research Report Cancer Research medicine.medical_specialty Time Factors Adolescent Clinical Investigations Preoperative care Young Adult Internal medicine Biopsy medicine Humans Prospective Studies Child Prospective cohort study Survival rate Aged Retrospective Studies Aged 80 and over Temozolomide medicine.diagnostic_test business.industry Retrospective cohort study Middle Aged Prognosis Chemotherapy regimen Surgery Survival Rate Treatment Outcome Oncology Concomitant Female France Neurology (clinical) Glioblastoma business medicine.drug |
| Zdroj: | Neuro-Oncology. 12:725-735 |
| ISSN: | 1523-5866 1522-8517 |
| DOI: | 10.1093/neuonc/noq030 |
| Popis: | This report, an audit requested by the French government, describes oncological patterns of care, prognostic factors, and survival for patients with newly diagnosed and histologically confirmed glioblastoma multiforme (GBM) in France. The French Brain Tumor DataBase, which is a national multidisciplinary (neurosurgeons, neuropathologists, radiotherapists, neurooncologists, epidemiologists, and biostatisticians) network, prospectively collected initial data for the cases of GBM in 2004, and a specific data card was used to retrospectively collect data on the management and follow-up care of these patients between January 1, 2004, and December 1, 2006. We recorded 952 cases of GBM (male/female ratio 1.6, median age 63.9 years, mean preoperative Karnofsky performance status [KPS] 79). Surgery consisted of resection (RS; n = 541) and biopsy (n = 411); 180 patients did not have subsequent oncological treatment. After surgery, first-line treatment (n = 772) consisted of radiotherapy (RT) and temozolomide (TMZ) concomitant +/- adjuvant in 314 patients, RT alone in 236 patients, chemotherapy (CT) alone in 157 patients, and other treatment modalities in 65 patients. Median overall survival was 286 days (95% CI, 266-314) and was significantly affected by age, KPS, and tumor location. Median survival (days, 95% CI) associated with these main strategies, when analyzed by a surgical group, were as follows: RS + RT-TMZ((n=224)): 476 (441-506), biopsy + RT-TMZ((n=90)): 329 (301-413), RS + RT((n=147)): 363 (331-431), biopsy + RT((n=89)): 178 (153-237), RS + CT((n=61)): 245 (190-361), biopsy + CT((n=96)): 244 (198-280), and biopsy only((n=118)): 55 (46-71). This study illustrates the usefulness of a national brain tumor database. To our knowledge, this work is the largest report of recent GBM management in Europe. |
| Databáze: | OpenAIRE |
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