Phenalenone derivatives and the unusual tricyclic sesterterpene acid from the marine fungus Lophiostoma bipolare BCC25910
| Autor: | Pranee Rachtawee, Palangpon Kongsaeree, Samran Prabpai, Chakapong Intaraudom, Tanapong Boonruangprapa, Pattama Pittayakhajonwut, Sutichai Nitthithanasilp |
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| Rok vydání: | 2014 |
| Předmět: |
Sesterterpenes
Stereochemistry Plasmodium falciparum Bacillus cereus Molecular Conformation Marine Biology Plant Science Fungus Microbial Sensitivity Tests Horticulture Crystallography X-Ray Biochemistry Microbiology Ascomycota Candida albicans Molecule Molecular Biology biology Strain (chemistry) Molecular Structure Biological activity General Medicine Phenalenes biology.organism_classification Thailand Anti-Bacterial Agents Drug Screening Assays Antitumor |
| Zdroj: | Phytochemistry. 120 |
| ISSN: | 1873-3700 |
| Popis: | Ten compounds including nine phenalenone derivatives (five bipolarides and four bipolarols) and a sesterterpene acid (bipolarenic acid), were isolated from a marine isolated of the fungus Lophiostoma bipolare (BCC25910), along with the known compounds, (-)-scleroderolide, (-)-sclerodin, and oxasetin. Chemical structures were elucidated based on NMR spectroscopic data and HRESIMS analysis. In addition, the absolute configurations of the phenalenones were resolved using specific rotations and chemical means, while the relative configuration of bipolarenic acid was confirmed by X-ray crystallographic analysis. The compounds were evaluated for biological activity against the Plasmodium falciparum K-1 strain, Candida albicans, and Bacillus cereus, and for cytotoxicity against both cancerous and non-cancerous cells. |
| Databáze: | OpenAIRE |
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