Cardiopreventive effects of camel milk against carbon tetrachloride induced oxidative stress, biochemical and histological alterations in mice
| Autor: | Zied Ghannoudi, Ahmed Gargouri, Khaled Bellassoued, Houda Hamed, Abdelfattah Elfeki, Manel Gargouri |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Camelus Cardiotonic Agents Antioxidant Physiology Thiobarbituric acid medicine.medical_treatment medicine.disease_cause digestive system 030226 pharmacology & pharmacy Antioxidants Protein Carbonylation Superoxide dismutase Lipid peroxidation Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine Lactate dehydrogenase parasitic diseases medicine Animals Rats Wistar Carbon Tetrachloride chemistry.chemical_classification biology Chemistry Myocardium Glutathione peroxidase Body Weight Heart Organ Size General Medicine Glutathione Oxidative Stress Milk 030104 developmental biology Endocrinology Biochemistry biology.protein Female Lipid Peroxidation Oxidative stress |
| Zdroj: | Archives of Physiology and Biochemistry. 124:253-260 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1080/13813455.2017.1395889 |
| Popis: | The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric acid reactive substances), protein carbonyl level and antioxidant markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and vitamin C) in the heart tissue. Moreover, CCl4 caused a distinguished rise of plasma aspartate aminotransferase, lactate dehydrogenase, troponin I, and creatine kinase activities. Furthermore, CM ameliorated biochemical and histological parameters as compared to CCl4-treated group. Overall, this study indicates that CM is efficient in inhibiting oxidative stress induced by CCl4 and suggests that the administration of this milk may be helpful in the prevention of cardio-toxicity complications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|