MicroRNAs: A Neoteric Approach to Understand Pathogenesis, Diagnose, and Treat Myocardial Infarction
| Autor: | Nida Irfan Sayed-Pathan, Pramod Kumar, Virendra Gajbhiye, Kishore M. Paknikar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Ventricular Remodeling business.industry Myocardium Myocardial Infarction Genetic Therapy Recovery of Function Bioinformatics medicine.disease Fibrosis Ventricular Function Left Pathogenesis MicroRNAs Gene Expression Regulation Predictive Value of Tests microRNA Animals Humans Regeneration Medicine Myocardial infarction Cardiology and Cardiovascular Medicine business Biomarkers Signal Transduction |
| Zdroj: | Journal of Cardiovascular Pharmacology. 78:773-781 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000001141 |
| Popis: | Myocardial infarction is a substantial contributor to ischemic heart diseases, affecting a large number of people leading to fatal conditions worldwide. MicroRNAs (miRNAs) are explicitly emerging as excellent modulators of pathways involved in maintaining cardiomyocyte survival, repair, and regeneration. Altered expression of genes in cardiomyocytes postinfarction can lead to the disordered state of the myocardium, such as cardiac hypertrophy, ischemia-reperfusion injury, left ventricular remodeling, and cardiac fibrosis. Therapeutic targeting of miRNAs in cardiomyocytes can potentially reverse the adverse effects in the heart postinfarction. This review aims to understand the role of several miRNAs involved in the regeneration and repair of cardiomyocytes postmyocardial infarction and presents comprehensive information on the subject. |
| Databáze: | OpenAIRE |
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