Density of microvessels positive for CD105 (endoglin) is related to prognosis in meningiomas
| Autor: | Serenella Cerasoli, Giovanni Tuccari, Valeria Barresi, Enrica Vitarelli |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
CD31 Pathology CD34 Antigens CD34 CD105 endoglin meningioma prognosis Kaplan-Meier Estimate Neovascularization Receptors 80 and over Meningeal Neoplasms Aged 80 and over Tumor Neovascularization Pathologic biology Middle Aged Prognosis Immunohistochemistry CD Cell Surface cardiovascular system Female Antibody medicine.symptom Adult medicine.medical_specialty Receptors Cell Surface survival Sensitivity and Specificity Pathology and Forensic Medicine Meningioma Cellular and Molecular Neuroscience Antigen Antigens CD Biomarkers Tumor medicine Humans Aged Capillaries Endoglin Antigens Pathologic business.industry medicine.disease biology.protein Neurology (clinical) business Biomarkers |
| Zdroj: | Acta Neuropathologica. 114:147-156 |
| ISSN: | 1432-0533 0001-6322 |
| Popis: | Microvessel density (MVD) is considered to be a prognostic marker in many tumours. Nevertheless, conflicting results were achieved regarding its prognostic role in meningiomas when it was quantified through pan-endothelial markers such as CD34, CD31 or Factor VIII. In the present study, MVD was assessed in meningiomas through the specific marker for neo-angiogenesis CD105. Fifty-four formalin fixed, paraffin embedded, surgical cases of meningiomas (WHO 28 grade I and 26 grade II) as well as ten normal leptomeningeal samples were submitted to immunohistochemical analysis for CD105. CD34 immuno-expression was also evaluated on consecutive parallel sections. For each case, MVD was estimated in terms of number of vessels/mm(2). CD105 was not evidenced in normal samples, whereas it was demonstrated in the vessels within 14/28 WHO grade I cases and within 24/26 WHO grade II meningiomas. On the contrary, CD34 antibody stained blood vessels in both normal and neoplastic samples; moreover, in each case, it stained more microvessels than CD105 antibody (25.33 +/- 21.16 vs. 50.72 +/- 26.75). Higher CD105 counts were significantly correlated with higher histological grade and Ki-67 LI > 4%. No statistical significant correlations were encountered between MVD measured by either CD105 and CD34 and sex, age, site of tumour or extent of surgical resection. CD105-MVD, but not CD34-MVD, showed an inverse significant correlation with overall survival and recurrence-free survival. In conclusion, our study suggests the higher specificity of CD105 in comparison to pan-endothelial markers in the evaluation of meningioma neo-angiogenesis, and its higher prognostic significance. CD105 might serve as a target for therapeutic approaches blocking blood supply in meningiomas. |
| Databáze: | OpenAIRE |
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