Impact of radiotherapy on normal brain tissue: semi-automated quantification of decrease in perfusion
| Autor: | Nedim C. M. Gulaldi, Mutlu Hayran, Elahi N, Ayse Aktas, Uysal U, Lale Atahan, Lale Kostakoglu, Uzal D, Bekdik Cf |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Brain tissue Single-photon emission computed tomography Basal (phylogenetics) Text mining Technetium Tc 99m Exametazime health services administration Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Cobalt Radioisotopes Adverse effect Child Tomography Emission-Computed Single-Photon medicine.diagnostic_test Radiotherapy business.industry Brain Neoplasms Remission Induction Brain Radiotherapy Dosage General Medicine Middle Aged Combined Modality Therapy Radiation therapy Total dose Regression Analysis Female Radiology Radiopharmaceuticals Nuclear medicine business Perfusion |
| Zdroj: | Annals of nuclear medicine. 14(1) |
| ISSN: | 0914-7187 |
| Popis: | We attempted to ascertain the impact of Co-60 conventional external radiotherapy (cRT) on the perfusion of normal brain tissue in relation to the radiation doses delivered to the tumors in patients with primary brain tumors.After surgery 18 patients (pts) were due to undergo cRT with a total dose of 5400- 6400 cGy. All the patients had a Tc-99m-HMPAO SPECT study prior to cRT (basal), 15th and 30th days of cRT as well as 1 (in 6 pts), 3 (in 9 pts), and 6 (in 3 pts) months after cRT. For quantitative evaluation, the entire set of transverse slices were divided into 4 regions as frontal, parietal, occipital and temporal regions by means of a computer software program. Semi-automated quantification was performed on a total of 1392 regions in 87 studies to determine left to right ratios. An interregional difference of at least 10% was considered abnormal.After elimination of tumor sites, 80 normal brain regions showed decreased perfusion after cRT. The percent decrease in perfusion was (mean 22.5+/-9.9) significantly higher in areas irradiated with doses3000 cGy (p0.05).cRT has adverse effects on the perfusion of normal brain tissue for doses500 cGy. Our findings justify treating patients with small and limited lesions with stereotactic radiotherapy in order to minimize the adverse effects of cRT on normal tissues. |
| Databáze: | OpenAIRE |
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